NCT06405594 · University of Maryland, College Park
Neurocognitive Mechanisms of Sentence Production Impairment in Aphasia
(sentence)
What this study is about
The proposed research is relevant to public health because stroke is a leading cause of long-term disability among older adults and communication impairments resulting from stroke have a significant negative impact on quality of life.
View original scientific description
The proposed research is relevant to public health because stroke is a leading cause of long-term disability among older adults and communication impairments resulting from stroke have a significant negative impact on quality of life. By seeking to better understand post-stroke aphasia, this project lays the groundwork for development of new interventions, and aligns with NIDCD's priority areas 1 (understanding normal function), 2 (understanding diseases), and 3 (improving diagnosis, treatment, and prevention).
Interventions
BEHAVIORAL
Language Condition
The intervention involves asking participants to speak and understand words and sentences with different linguistic manipulations such as morphological, semantic, phonological priming, predictability of the subject and object nouns associated with verbs, naming of verbs and nouns, production of sentences with past, future or present tense. Accuracy, response times and brain activity are the outcome measures.
Primary outcome measures
Accuracy
Time frame: through the completion of the study, an average of 1 year
Response accuracy for each experimental condition will be measured
Response time
Time frame: through the completion of the study, an average of 1 year
Response times for each experimental condition will be measured
Brain activity
Time frame: through the completion of the study, an average of 1 year
Patterns of brain activity (using magnetoencephalography and MRI) will be measured for each experimental condition
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- At least 18 years of age
- Persons with acquired aphasia are defined as those with a language impairment following left hemisphere brain injury (most likely a stroke).
- Neurotypical adults need to be either young (ages 18-30 years) or older (\> 60 years)
- Native (or primary) speakers of English
Exclusion criteria
- Prior neurological or psychiatric diagnoses or developmental disabilities before the onset of aphasia
- do not speak English fluently
Where
- College Park, Maryland
Collaborators
McMaster University
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Sep 3, 2024 · Source of record for eligibility and locations