NCT04532424 · Stanford University
Transcranial Magnetic Stimulation for Restricted and Repetitive Behavior in ASD
(TMS for ASD)
What this study is about
Investigating the effectiveness of a form of TMS called theta-burst stimulation for restricted and repetitive behavior in ASD.
View original scientific description
Investigating the efficacy of a form of TMS called theta-burst stimulation for restricted and repetitive behavior in ASD.
Interventions
DEVICE
Transcranial magnetic stimulation
Non-invasive brain stimulation technique that is FDA-approved for the treatment of refractory depression, OCD and migraine.
Primary outcome measures
Repetitive Behavior Scale-Revised (RBS-R)
Time frame: Up to one month post-treatment
44-item parent-report questionnaire to measure restricted and repetitive behavior in ASD. We predict that each TMS target will selectively reduce the subscale being targeted.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Diagnosis of Autism Spectrum Disorder (ASD)
- Meet criteria for Autism Spectrum Disorder (ASD) on clinical assessments (ADOS-2 or CARS if conducted remotely \& ADI-R)
- Aged between 12-45 years old
- Have a reliable informant who can complete relevant questionnaires
- Have DARB scores which indicate high levels (50% or above) of RRB on one of the following domains: Insistence on Sameness, Obsessive Compulsive Behaviors, and Unusual Interests
Exclusion criteria
- Any contraindications for TMS e.g. history of seizures other than clear substance-induced/fever-induced seizures with neurologist note or normal clean EEG and no seizure in at least 12 months prior to enrollment.
- Any current or past history of any physical condition which in the investigator's opinion might put the subject at risk or interfere with study results interpretation.
- Active substance use (\<1 week) or intoxication verified by toxicology screen--of cocaine, amphetamines, benzodiazepines.
- Showing symptoms of withdrawal from alcohol or benzodiazepines.
- DSM-5 diagnosis of bipolar disorder or a psychotic disorder e.g. schizophrenia.
- Significant sensory impairments such as blindness or deafness.
- Current severe insomnia (must sleep a minimum of 4 hours the night before stimulation).
- Not willing to cooperate with the TMS procedures.
- Currently taking Clozapine or another medication that the PI determines increases the risk of TMS or may disrupt the efficacy.
- A motor threshold that is too high to allow safe/tolerable treatment.
- Conditions that increase the risk for COVID-19 (in accordance with university guidelines).
Where
- Stanford, California
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Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Aug 19, 2025 · Source of record for eligibility and locations