Boston, MANCT05664516Now EnrollingIRB Ready

Binge-eating Disorder Clinical Trial in Boston, MA

Access cutting-edge binge-eating disorder treatment through this clinical trial at a research site in Boston. Study-provided care at no cost to qualified participants.

Sponsored by Massachusetts General Hospital

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Expert Care in Boston

Access binge-eating disorder specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related binge-eating disorder treatment provided free

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Check if you qualify for this binge-eating disorder clinical trial in Boston, MA

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Why Participate?

  • No-Cost Study Care

  • Local to Boston

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Boston site if eligible
  4. 4Begin participation

About This Binge-eating Disorder Study in Boston

This study evaluates the impact of intranasal oxytocin vs placebo in patients with binge eating disorder or episodes of binging. We hypothesize that 8 weeks of intranasal oxytocin vs placebo will improve clinical outcomes \[reduction in bingeing frequency\], and have a satisfactory safety and tolerability profile. We will also explore the predictive value of changes in homeostatic appetite, reward sensitivity, and impulse control, the identified underlying mediators, as assessed 4 weeks into the intervention, for treatment success after 8 weeks of the intervention.

Sponsor: Massachusetts General Hospital

Who Can Participate

Inclusion Criteria

Males and females, 18-70 years old
BMI greater than or equal to 18.5
BED as assessed by Structured Clinical Interview for DSM-5 Disorders (SCID-5-RV) OR Other Specified Feeding or Eating Disorder (OSFED) - Binge-eating disorder (of low frequency and/or limited duration) (SCID-5-RV) OR Bulimia Nervosa (BN) through excessive exercise and/or fasting to avoid gaining weight after episodes of binge eating. For individuals with OSFED-BED, the frequency of subjective and objective binge eating episodes will meet the frequency (Criterion D) for BED.

Exclusion Criteria

Substance use disorder active within the last 6 months, or clinical suspicion of ongoing substance use disorder at the discretion of the study clinician at the time of screening based on history and/or laboratory results
Medication changes that have not reached steady state concentration, measured by the equivalent of 5 half-lives of that medication
Use of medications for binge eating disorder or weight loss unless at a stable dose for at least 12 weeks
History of any of the following medical conditions: inflammatory bowel disease or untreated thyroid disease
Uncontrolled epilepsy (as defined by a seizure within the last 12 months)
Clinically relevant ventricular arrhythmias, coronary heart disease, known long QTc, and hypertrophic cardiomyopathy
Hematocrit \>2% below normal
Hemoglobin A1c \>8%
Use of insulin
ALT or AST \>2.5 times upper limit of normal
Glomerular filtration rate \< 60 mL/min
Hyponatremia. Note that, in order to be randomized, subjects must have Na ≥ 135 mEq/L.
Pregnancy or breastfeeding
Unwilling to use a medically acceptable form of contraception throughout the study period (female of child-bearing potential only)
History of psychosis or active suicidal ideation
Major depressive disorder likely to require initiation or change in active treatment
Borderline personality disorder as assessed by the McLean Screening Instrument for Borderline Personality Disorder (MSI-BPD)
Current nicotine use, unless stable use for at least 12 weeks.
Participation in any clinical study involving an investigational drug, device, or biologic within 1 month of randomization
Any significant illness, condition, or medication that the Investigator determines could interfere with study participation and impact data collection or subject safety

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT05664516) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Binge-eating Disorder Treatment Options in Boston, MA

If you're searching for binge-eating disorder treatment options in Boston, MA, this clinical trial (NCT05664516) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced binge-eating disorder specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all binge-eating disorder clinical trials near you to find additional studies recruiting in your area.

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