NCT05598879 · The Cleveland Clinic
Global Cardio Oncology Registry
(G-COR)
What this study is about
G-COR is the first Global forward-looking Cardio-Oncology Registry. It is a multinational, conducted at multiple hospitals forward-looking observational group of participants registry, with the goal of collecting clinical, laboratory, imaging, demographic, and socioeconomic data to identify risk factors associated with increased incidence of cancer therapy related cardiovascular toxicity (CTR-CVT) in different settings and to derive and validate risk scores for cardio oncology patients treated in different geographic locations throughout the world.
View original scientific description
G-COR is the first Global Prospective Cardio-Oncology Registry. It is a multinational, multicenter prospective observational cohort registry, with the goal of collecting clinical, laboratory, imaging, demographic, and socioeconomic data to identify risk factors associated with increased incidence of cancer therapy related cardiovascular toxicity (CTR-CVT) in different settings and to derive and validate risk scores for cardio oncology patients treated in different geographic locations throughout the world.
Interventions
OTHER
anonymized data collection during programmed surveillance clinical follow up
anonymized data entry of demographic, clinical, imaging, laboratory, cancer treatment, and cardiovascular events into a RedCap Cloud platform
Primary outcome measures
Cardiotoxicity
Time frame: 18 months of prospective follow up
Any new cardiac event occurring during or after cancer treatment
New cardiovascular events
Time frame: 18 months of prospective follow up
Heart failure, myocardial infarction, cardiac arrhythmias, syncope, coronary revascularization, heart transplant, cerebrovascular accident, peripheral arterial disease, hypertension, pulmonary hypertension. All events will be adjudicated according to standard clinical definitions.
Cardiovascular death.
Time frame: 18 months of prospective follow up
Death during or after cancer treatment, adjudicated to cardiovascular causes by treating physicians.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- New cardio-oncology consultation for breast cancer patients, or
- New cardio-oncology consultation for Hodgkin's or non-Hodgkin's lymphoma patients, or
- New cardio-oncology consultation for acute or chronic leukemia patients, or
- New cardio-oncology consultation for multiple myeloma or AL amyloidosis, or
- New cardio-oncology consultations for immune check-point inhibitors cardiac evaluation.
- All patients have to be 18 years old or older
Exclusion criteria
- Cardio-oncology patients who have previously had cardio-oncology evaluation and follow up by the investigators.
- Minors less than 18 years old.
- Inability or unwillingness to consent to participate
Where
- Weston, Florida
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced May 12, 2026 · Source of record for eligibility and locations