Is NCT05250037 recruiting in Houston, TX?

Yes, NCT05250037 is currently recruiting participants at its Houston, TX location. This bronchiolitis obliterans syndrome clinical trial is actively enrolling qualified participants.

Is participation in this Houston clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Bronchiolitis Obliterans Syndrome Clinical Trial in Houston, TX

Q: How do I join the bronchiolitis obliterans syndrome clinical trial in Houston?

To join this clinical trial in Houston, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

About This Bronchiolitis Obliterans Syndrome Study in Houston

This observational trial studies whether respiratory viruses are the cause of lung disease (bronchiolitis obliterans syndrome \[BOS\] or graft-versus-host disease of the lung) and changes in lung function in patients who have received a donor stem cell transplant. Patients with chronic graft-versus-host disease (cGVHD) are at higher risk of developing BOS. Studies have also shown that patients who had a respiratory viral illness early after their transplant are at higher risk of developing lung problems later on. Patients who are at risk and who already have BOS might benefit from being monitored more closely. Spirometry is a way of assessing a patient's lung function and is often used to diagnose lung disease. Spirometry measured at home with a simple handheld device may reduce the burden of performing pulmonary function testing at a facility and potentially help patients get their lung disease diagnosed and treated sooner.

Sponsor: Fred Hutchinson Cancer Center

Who Can Participate

Inclusion Criteria

Allogeneic HCT recipients with any indication, graft source, donor type, or conditioning regimen

Age 8 and older

COHORT 1 Inclusion criteria: One or more of the following clinical scenarios that encompass increased risk for BOS:

A diagnosis of cGVHD as per NIH criteria through 5 years of diagnosis. i. New diagnosis of cGVHD within 3 months. This window may be extended by 30 days on a case-by-case basis. ii. A diagnosis of cGVHD ≥ 3 months and ≤ 5 years, with a new FEV1 decline of ≥10% in absolute value within 6 weeks compared with PFT done within the prior 2 years. iii. A recent documented respiratory infection of any etiology that has been clinically managed and stabilized or improving as determined by a clinician, within 8 weeks. iv. Progression of flare of chronic GVHD requiring an alteration in therapy as determined by a clinician, within 3 months.

At 'Day 80' evaluation. D80 designates a posttransplant landmark, usually between 70-120 days, in which patients are evaluated for discharge back to community care. Patients with the following occurrences can be enrolled with 3 months of the Day 80 post-transplant evaluation. i. FEV1 decline of 10% in absolute values compared with pretransplant baseline. ii. Documented posttransplant RVI. iii. Lower respiratory tract disease (LRTD) of any etiology.

COHORT 2 inclusion criteria: Newly diagnosed BOS within 6 weeks of clinical recognition. This may include the following scenarios:

"Early BOS", ie patients with new airflow decline and obstruction, not yet meeting the FEV1 cut-off of \< 75% predicted by FEV1, in the absence of other etiologies as determined by clinical investigations including chest imaging and microbiologic studies.

NIH-defined BOS: i. FEV1 \< 75% predicted, with a decline in absolute FEV1 \> 10% compared to pretransplant baseline or within the prior 2 years. Absolute decline in FEV1 should remain \>10% after bronchodilator response. ii. FEV1/FVC or FEV1/VC \<0.7, or Lower Limit of Normal as per accepted reference standards. Reference standards may include National Health and Nutrition Examination Survey III or Global Lung Initiative. iii. Absence of an alternative diagnosis, including COPD exacerbation, asthma, and active respiratory tract infection, as determined by appropriate clinical investigations that may include chest imaging, microbiologic cultures, and/or bronchoscopy. iv. One of two supportive features of BOS:

a. Evidence of air trapping by PFTs: RV\>120%, or elevated RV/TLC (\>20% of predicted value)

b. High resolution chest CT with inspiratory and expiratory cuts that show findings that are consistent with small airways disease including (but not exclusive of) air trapping, bronchial wall thickening, or bronchiectasis.

BOS with atypical spirometric pattern i. FEV1 \<80%, with a preserved FEV1/FVC ratio (≥0.7) and TLC ≥80% in the absence of other clinically determined lung disease.

Clinical or suspected diagnosis of BOS not otherwise meeting above criteria.

Patient should have an Android or iOS-based smartphone with reliable access to Wi-Fi for data to be transmitted electronically. Android smartphones should have a software version of 4.0 or higher; iOS phones should have a version of 8.0 or higher.

Patient should be willing and able to communicate electronically in English or Spanish.

Exclusion Criteria

Diagnosis of BOS at time of enrollment (Cohort 1 only)

Life expectancy \< 2 years.

Diagnosis of active hematologic relapse or malignancy requiring active treatment that will affect that patient's ability to comply with study procedures.

Patient should not have a clinically acute active lower respiratory tract infection or a clinically acute active noninfectious respiratory condition (i.e. COPD exacerbation, pleural effusion) at the time of enrollment. However, patient may become eligible once these conditions have stabilized or resolved as noted above.

Inability or unwillingness to perform the study procedures, most of which are performed at home.

Lack of a personal iOS or Android smartphone.

Inability or unwillingness to communicate electronically.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Houston?

Yes, this clinical trial (NCT05250037) has an active research site in Houston, TX that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Bronchiolitis Obliterans Syndrome Treatment Options in Houston, TX

If you're searching for bronchiolitis obliterans syndrome treatment options in Houston, TX, this clinical trial (NCT05250037) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Houston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced bronchiolitis obliterans syndrome specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all bronchiolitis obliterans syndrome clinical trials near you to find additional studies recruiting in your area.

Bronchiolitis Obliterans Syndrome Clinical Trial in Houston, TX

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