NCT06566612 · University of California, San Diego
Avoidance-driven Decision Making and Learning in Anorexia Nervosa and Bulimia Nervosa
What this study is about
The purpose of this study is to investigate areas of the brain responsible for avoidance learning in adults with eating disorders using brain imaging techniques, computer tasks, and self-report questionnaires and interviews. The investigators will study changes in brain activity using a procedure called functional magnetic resonance imaging (fMRI).
View original scientific description
The purpose of this study is to investigate areas of the brain responsible for avoidance learning in adults with eating disorders using brain imaging techniques, computer tasks, and self-report questionnaires and interviews. The investigators will study changes in brain activity using a procedure called functional magnetic resonance imaging (fMRI). This study will include 78 women with an eating disorder (26 with anorexia nervosa \[AN\], 26 with bulimia nervosa \[BN\]) and 26 healthy controls (HC) aged 18-39. Aim 1: Evaluate behavioral differences in active and passive avoidance learning in eating disorders and associations with symptoms. Aim 2: Evaluate whether corticostriatal and limbic-prefrontal fMRI BOLD response associated with avoidance learning differs in eating disorders relative to healthy controls and relates to symptoms. Aim 3: Evaluate whether functional connectivity of avoidance learning neural circuity differs in eating disorders relative to healthy controls.
Primary outcome measures
Learning rate
Time frame: 25 minutes
Behavioral responses during a card game gambling task
fMRI brain response
Time frame: 25 minutes
fMRI brain activity associated with the card game gambling task
Brain connectivity
Time frame: 10 minutes
Whole-brain functional connectivity associated with the card game gambling task
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Eating Disorder Group:
- Between the ages of 18 and 39 years old
- Meet DSM-V criteria for anorexia nervosa or bulimia nervosa Healthy Controls:
- Between the ages of 18 and 39 years old
- Have maintained 85% to 120% ideal body weight since menarche
Exclusion criteria
- Psychotic illness/other mental illness requiring hospitalization
- Current dependence on drugs or alcohol defined by DSM IV criteria. Additionally, positive test results for drug use on the day of the scan, apart of marijuana, will result in cancelling or rescheduling the scan because acute use will impact MRI measures.
- Physical conditions (e.g. diabetes mellitus, pregnancy) known to influence eating or weight
- Neurological disorder, neurodevelopmental disorder, or history of head injury with \>30 min loss of consciousness
- Any contraindication to undergoing an MRI
- Primary obsessive compulsive disorder or primary major depressive disorder Additional Exclusion Criteria for ED Group:
- If taking other psychotropic medication, any change in dosage in the 2 weeks before scanning Additional Exclusion Criteria for Healthy Control Group:
- Meet criteria for the diagnosis of any psychiatric disorder currently
- Any history of binge eating or purging behaviors, including self-induced vomiting, laxative or diuretic misuse
- Use of any psychoactive or other medication known to affect mood or concentration in the last 3 months
Where
- La Jolla, California
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced May 1, 2026 · Source of record for eligibility and locations