NCT03750981 · Barbara Ann Karmanos Cancer Institute
C.A.P.A.B.L.E. (CrossFit® and Physical Activity: A Better Life Experience)
(CAPABLE)
What this study is about
This study will introduce cancer survivors to cross-training with the expectation that the program proposed will ultimately result in superior improvements in functional performance, body composition and quality of life compared with the current American Cancer Society (ACS) guidelines for cancer survivors.
View original scientific description
This study will introduce cancer survivors to cross-training with the expectation that the program proposed will ultimately result in superior improvements in functional performance, body composition and quality of life compared with the current American Cancer Society (ACS) guidelines for cancer survivors.
Interventions
BEHAVIORAL
12 week pilot intervention study.
Participants will begin a 12-week high-intensity functional training program conducted at CrossFit® in the D, located in downtown Detroit, Northville Athletix in Northville and Five Lakes CrossFit® in Farmington Hills.
Primary outcome measures
Enrollment rates
Time frame: Baseline
Enrollment rates will be calculated among those who respond to notices about the study and adherence to the program among those who enroll and to describe reported barriers to participation among respondents who do not ultimately enroll
Change in functional performance and variability in functional performance among adult cancer survivors enrolled in a high-intensity functional training program
Time frame: Baseline to 12 weeks
Physical measures of strength will be assessed by a certified trainer. To assess strength improvements deadlifts (lifting weights from floor to waist) will be performed in 10 lb. increments. A circuit will also be done with strength measures including sit ups and push ups.
Change in functional performance and variability in functional performance among adult cancer survivors enrolled in a high-intensity functional training program
Time frame: Baseline to 12 weeks
Physical measures of flexibility will be assessed by a certified trainer. To assess flexibility sit ups, squats and push up level (floor, knees, on an elevated bar, etc) will be recorded.
Change in functional performance and variability in functional performance among adult cancer survivors enrolled in a high-intensity functional training program
Time frame: Baseline to 12 weeks
Physical measures of cardiovascular strength will be assessed by a certified trainer. To assess cardiovascular strength maximum effort on a stationary bike will be recorded. Additionally, in the circuit, a maximum effort on a rowing machine will be recorded.
Change in self-reported health-related quality of life (HRQOL) and variability using the FACT questionnaire
Time frame: Baseline to 12 weeks
Quality of Life will be measured using the Functional Assessment of Cancer Therapy: General (FACT), developed by Dr. David Cella. The FACT-G is 27 items assessing physical, social/ family, emotional and functional well-being. The survey uses a five-point scale from 0 (not at all) to 4 (very much). Scoring the FACT-G is performed through a sum of item scores. Higher scores indicate a better health state.
Change in Body Composition
Time frame: Baseline to 12 weeks
Changes in weight in kg
Change in Body Composition
Time frame: Baseline to 12 weeks
Changes in body fat percentage
Change in Body Composition
Time frame: Baseline to 12 weeks
Changes in visceral fat percentage
Change in Body Composition
Time frame: Baseline to 12 weeks
Changes in muscle mass percentage
Change in Body Composition
Time frame: Baseline to 12 weeks
Changes in body mass index (BMI) - Weight and height will be combined to report BMI in kg/ m2
Change in Body Composition
Time frame: Baseline to 12 weeks
Changes in resting metabolism value
Change in Motivation
Time frame: Baseline to 12 weeks
Motivation to exercise will be collected via a survey
Satisfaction with the Program
Time frame: 12 weeks
Satisfaction with the program will be collected via a survey
Program Adherence
Time frame: 12 weeks
Program adherence will be calculated based on how many sessions each participant attended in the 13 week program, 36 session design.
Height
Time frame: Baseline
Height will be collected in meters to use in the calculation of Body Mass Index
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Aged 18 years or older at time of program recruitment
- Diagnosed with any cancer
- Cleared from their physician to participate in the program (We assume that most patients will have completed treatment, however if a patient is currently under treatment, this should be their oncologist. If the patient is not currently undergoing treatment, this could be primary care physician or oncologist).
- Available transportation to and from the facility on session days
Exclusion criteria
- Widely metastatic cancers to the brain or bone may be excluded.
- Patients using mobility assistance devices may be excluded. Exclusionary criteria will be reviewed on a case-by-case basis and patients with these limitations may be included with approval from Dr. Beebe-Dimmer and the referring physician.
Where
- Detroit, Michigan
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Nov 6, 2025 · Source of record for eligibility and locations