Tucson, AZNCT05486572Now EnrollingIRB Ready

Carcinoma, Hepatocellular Clinical Trial in Tucson, AZ

Access cutting-edge carcinoma, hepatocellular treatment through this clinical trial at a research site in Tucson. Study-provided care at no cost to qualified participants.

Sponsored by VA Office of Research and Development

Quick Self-Assessment

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Expert Care in Tucson

Access carcinoma, hepatocellular specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related carcinoma, hepatocellular treatment provided free

Apply for This Tucson Location

Check if you qualify for this carcinoma, hepatocellular clinical trial in Tucson, AZ

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Tucson

    Convenient for AZ residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Tucson site if eligible
  4. 4Begin participation

About This Carcinoma, Hepatocellular Study in Tucson

The study is a randomized trial of two different screening methods for early detection of liver cancer in patients with cirrhosis of the liver. The goal of PREMIUM is to compare an abbreviated version of the diagnostic gold standard for HCC (aMRI) +AFP to the standard-of-care screening (US+AFP) in patients at high risk of developing HCC. The investigators hypothesize that HCC will be detected at earlier stages, allowing for more curative treatments and resulting in a reduction in HCC-related mortality.

Sponsor: VA Office of Research and Development

Who Can Participate

Inclusion Criteria

Cirrhosis due to any underlying etiology diagnosed by one or more of the following:
Histology of liver biopsy
Radiologic criteria (nodular liver, evidence of portal hypertension)
Clinical signs of cirrhosis (gastroesophageal varices, ascites, hepatic encephalopathy)
Vibration controlled transient elastography (VCTE, specifically Fibroscan, which is available in all participating sites) with liver stiffness \>12.5kPa or magnetic resonance elastography \>5.0 kPa
High Risk of Liver Cancer: This will be defined by one or more of the following:
Current HCV infection (detectable HCV RNA)
FIB-4 score 3.25, within 6 months of randomization
Estimated annual HCC incidence \>2.5%, within 6 months of randomization, calculated by VA-specific models that the investigators developed (available on the national VA ALD Dashboard and at www.hccrisk.com).
Able to provide informed consent

Exclusion Criteria

Prior diagnosis or of HCC
Current suspicion of HCC
Prior receipt of organ transplantation
Currently listed for organ transplantation.
Participation in a conflicting HCC screening trial
Advanced liver dysfunction, defined by Child C Cirrhosis (CTP score 10), or MELD score \>20, within 6 months prior to randomization
Glomerular Filtration Rate (GFR) \<30 ml/min
Multiple comorbid conditions resulting in limited life expectancy, defined by a cirrhosis-specific comorbidity index (CirCom)112 score 3. Of note, early stage malignancies of the bladder, lung, or prostate will not be excluded.
Estimated life expectancy \<5 years as determined by the clinical judgement of the Study Investigator
Contraindications to undergoing contrast-enhanced MRI:
Allergy to gadolinium-based contrast agents
MRI-incompatible implantable devices (e.g. pacemakers, defibrillators, resynchronization devices)
Implantable neurostimulation device
Implantable cochlear implant/ear implant
Drug infusion pumps (e.g. insulin pump, analgesic or chemotherapy pumps)
Metallic foreign bodies in or around the eye
Metallic fragments, such as bullets, shotgun pellets or shrapnel
Metallic body piercings that cannot be removed
Cerebral artery aneurysm clips
Severe claustrophobia
Unable to fit on MRI machine due to weight (weight \>400lbs) or body habitus
Inability to complete planned study visits (e.g. lives too far from VA, no transportation, etc.)
Currently pregnant

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Tucson?

Yes, this clinical trial (NCT05486572) has an active research site in Tucson, AZ that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Carcinoma, Hepatocellular Treatment Options in Tucson, AZ

If you're searching for carcinoma, hepatocellular treatment options in Tucson, AZ, this clinical trial (NCT05486572) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Tucson research site is actively enrolling participants for this clinical trial. You'll receive care from experienced carcinoma, hepatocellular specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

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Secure · Expert Care · Tucson, AZ