NCT07114510 · Children's Hospital of Philadelphia
Optimal Ventilation for Cardiac Arrest
(OPTI-VENT)
What this study is about
Pediatric cardiac arrest is a life-threatening problem affecting \>15,000 hospitalized children each year. Less than half of these children survive to hospital discharge, and neurologic morbidity is common among survivors.
View original scientific description
Pediatric cardiac arrest is a life-threatening problem affecting \>15,000 hospitalized children each year. Less than half of these children survive to hospital discharge, and neurologic morbidity is common among survivors. The objective of this study is to evaluate the effectiveness of the OPTI-VENT bundle to improve survival to discharge with favorable neurological outcome (Pediatric Cerebral Performance Category Score 1-2 or no change from baseline) among children receiving at least 1 minute of CPR.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Invasive airway in place at the start of CPR or airway placed within the first 5 minutes
- Received at least 1 minute of CPR.
Exclusion criteria
- Lack of commitment to aggressive ICU therapies (e.g., CPR performed as part of end-of-life care.
- Brain death determination prior to the CPR event.
- Out-of-hospital cardiac arrest was the reason for initial admission to the hospital (known poor outcomes).
- Supported by Veno-Arterial Extra Corporeal Membrane Oxygenation at the start of CPR
Where
- Orange, California
- Palo Alto, California
- Denver, Colorado
- Wilmington, Delaware
- Atlanta, Georgia
- Indianapolis, Indiana
- Iowa City, Iowa
- Boston, Massachusetts
- St Louis, Missouri
- New Hyde Park, New York
- Chapel Hill, North Carolina
- Cincinnati, Ohio
And 7 more locations — see the full list below.
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Oct 8, 2025 · Source of record for eligibility and locations