NCT05169333 · University of Oxford
The Oxford Risk Factors And Non-Invasive Imaging Study
(ORFAN)
What this study is about
ORFAN is a forward-looking, multi-centre, multi-ethnic group of participants observational study collecting CT scans, biological material and outcomes data, to develop and validate novel biomarkers of cardiometabolic and other disease risk.
View original scientific description
ORFAN is a prospective, multi-centre, multi-ethnic cohort observational study collecting CT scans, biological material and outcomes data, to develop and validate novel biomarkers of cardiometabolic and other disease risk.
Primary outcome measures
Cardiac and all cause mortality
Time frame: 15 years
Using novel image analysis methods, clinical risk factors, and blood biomarkers to predict future cardiac and all-cause mortality over a period of 15 years post CT scan.
Non-fatal vascular events
Time frame: 15 years
Using novel image analysis methods, clinical risk factors, and blood biomarkers to predict future non-fatal vascular events over a period of 15 years post CT scan.
Cardiac and non-cardiac findings by Computed Tomography
Time frame: 15 years
Using novel image analysis methods, clinical risk factors, and blood biomarkers to detect pathology from Computed Tomography images.
Progression of disease
Time frame: 15 years
Using novel image analysis methods, clinical risk factors, and blood biomarkers to predict progression of cardiometabolic diseases over a period of 15 years post index CT scan.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Participant is willing and able to give informed consent for participation in the study.
- Male or Female, aged 18 -99 years. Inclusion Criteria for study Arm 4: • Male or Female, aged 18 -99 years.
Exclusion criteria
- Unable or unwilling to consent
- Active cancer Exclusion Criteria for Study Arm 4:
- Participation in Study Arms 1, 2 or 3
- Existing opt-out from use of data for research purposes
Where
- Phoenix, Arizona
- New Haven, Connecticut
- Tampa, Florida
- Atlanta, Georgia
- Kansas City, Kansas
- Bethesda, Maryland
- Boston, Massachusetts
- Cleveland, Ohio
- Dallas, Texas
- San Antonio, Texas
- Charlottesville, Virginia
Collaborators
Caristo Diagnostics Limited, Oxford University Hospitals NHS Trust, British Heart Foundation, Innovate UK, European Commission
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jul 31, 2026 · Source of record for eligibility and locations