NCT04852354 · Weill Medical College of Cornell University
Tissue Collection for Drug Screening and Bioanalysis
What this study is about
The purpose of this study is to improve upon the knowledge currently available about central nervous system (CNS) tumors. We will study the different characteristics of these tumors using tissue samples collected during surgery and post-autopsy. The aim is to create tumor cell lines and models to test how they respond to different drugs.
View original scientific description
The purpose of this study is to improve upon the knowledge currently available about central nervous system (CNS) tumors. We will study the different characteristics of these tumors using tissue samples collected during surgery and post-autopsy. The aim is to create tumor cell lines and models to test how they respond to different drugs. This research will help improve treatment options and identify new targets for therapy.
Primary outcome measures
Evaluating and characterizing the genetic, immunohistochemical, cellular, and molecular profiles of pediatric neoplastic lesions
Time frame: Through study completion, average 1-3 years
To develop patient-derived tissue cell lines and xenografts
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- for Tumor patients undergoing neurosurgery (cohort 1)
- Subject has presented with a suspected/confirmed neoplastic CNS lesion and is undergoing a neurosurgical procedure in which CNS tissue and/or tumors associated with this tissue will be removed.
- There must be tissue available in excess of that required by neuropathology for diagnostic purposes.
- Subject of all ages included.
- Subjects who are pregnant can be included.
- Subjects who are neonates (0-4 weeks) can be included. Inclusion Criteria for Non-tumor patients undergoing neurosurgery (cohort 2)
- Subject is between 4 weeks and 21 years of age and is undergoing a neurosurgical procedure at WCMC.
- Subject does not have a CNS tumor diagnosis.
- Subject should not be pregnant at the time of enrollment. Inclusion Criteria for Autopsy tumor tissue donation (cohort 3)
- Subject of all ages included
- Subject has been diagnosed with a neoplastic CNS lesion at the time of passing.
- Subjects who are pregnant can be included.
- Subjects who are neonates (0-4 weeks) can be included. Inclusion Criteria for parent of tumor patients
- Subject is the biological parent of a patient undergoing/ who underwent a neurosurgical procedure in which CNS tissue and/or tumors associated with this tissue will be/ was removed.
- Subject is the biological parent of patient enrolled in cohort 1.
- Subject is not pregnant at the time of enrollment.
Where
- New York, New York
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Dec 17, 2025 · Source of record for eligibility and locations