NCT06288763 · Washington University School of Medicine
Nerve Transfer to Improve Function in High Level Tetraplegia
What this study is about
The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury.
View original scientific description
The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury. Participants will: * undergo standard of care pre- and post-op testing and study exams * complete pre- and post-questionnaires * undergo standard of care nerve transfer surgeries * follow-up with surgeon at 6/12/18/24/36 and potentially at 48 months * attend therapy at local therapist for up to 2 years postop.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- 18-80 years of age
- High cervical SCI (motor level C1-C4)
- Motor complete SCI AIS grade A-B
- Plateaued spontaneous recovery for at least 6 months of non-operative therapy
- SCI greater than 6 months and fewer than 60 months since injury
- At least MRC 4/5 donor strength
- Mentally and physically willing and able to comply with evaluations
Exclusion criteria
- Active infection at the operative site or systemic infection
- Any return or ongoing recovery of distal motor function
- Significant joint contractures and/or limitations in passive range of motion in the arm
- Mentally or physically compromised making it impossible to complete study activities
- Immunologically suppressed
- Currently undergoing long-term steroid therapy
- Active malignancy
Where
- Stanford, California
- Miami, Florida
- Baltimore, Maryland
- Ann Arbor, Michigan
- St Louis, Missouri
- Winston-Salem, North Carolina
- Philadelphia, Pennsylvania
- Houston, Texas
- Salt Lake City, Utah
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Mar 11, 2026 · Source of record for eligibility and locations