New York, NYNCT06456073Now EnrollingIRB Ready

Chronic Anal Fissure Clinical Trial in New York, NY

Access cutting-edge chronic anal fissure treatment through this phase 1 clinical trial at a research site in New York. Study-provided care at no cost to qualified participants.

Sponsored by Weill Medical College of Cornell University

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Expert Care in New York

Access chronic anal fissure specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related chronic anal fissure treatment provided free

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Check if you qualify for this chronic anal fissure clinical trial in New York, NY

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to New York

    Convenient for NY residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit New York site if eligible
  4. 4Begin participation

About This Chronic Anal Fissure Study in New York

This clinical trial is being conducted by investigators who are colorectal surgeons. Eligible study participants will receive the experimental treatment E-CEL UVEC cells by direct injection into the anal fissure. The study is being conducted to determine if E-CEL UVEC cell injections will be safe and would have any effects on healing of the anal fissure.

Sponsor: Weill Medical College of Cornell University

Who Can Participate

Inclusion Criteria

Adults 18 years and older
Anterior or posterior chronic anal fissure (CAF) - chronicity defined as presence of anal fissure ≥ 6 weeks
Inadequate response to medical treatment of anal fissure (1 month of failed vasodilator treatment plus declined or failed botulinum injection treatment)
Recent history of pain on defecation at a level 4 or higher on the numerical rating scale (NRS)
Vital signs upon screening:
Blood pressure: systolic ≥ 90 and \< 140; and diastolic ≥ 60 and \< 90.
Breathing: ≥ 12 and ≤ 20 breaths per minute.
Pulse: ≥ 60 and ≤ 100 beats per minute.
Temperature: ≥ 97.8°F and ≤ 99.1°F (36.5°C to 37.3°C)
O2 saturation: \> 92%
Willing to take adequate contraceptive measures
Willing to sign an informed consent form and follow instructions for the trial including appearing for visits and filling out questionnaires

Exclusion Criteria

Lateral anal fissure
Presence of peri-anal or rectovaginal fistula, rectal or anal stenosis, or peri-anal abscess or non-healing peri-anal post-surgical wounds that are not anal fissures (subjects with history of anorectal surgery with healed surgical wound is not excluded)
Active, untreated or medically unresponsive infection of the anal fissure or fistula (e.g., erythema and pus)
Active systemic infection (e.g., bacteremia, sepsis) - stable, controlled and treated HIV+ subjects (e.g., recent plasma HIV RNA \<200 copies/mL) are not excluded
Presence of inflammatory bowel diseases (e.g., Crohn's, ulcerative colitis)
Taking systemic chemotherapy or local pelvic radiation treatments
Renal impairment defined by serum creatinine ≥ 1.5 x upper limit of normality (ULN)
Hepatic impairment defined by both of the following laboratory ranges: (a) total bilirubin ≥ 1.5 x ULN unless benign congenital hyperbilirubinemia; and (b) aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≥ 2.5 x ULN
Active alcohol or substance use that, in the opinion of the site investigator, will interfere with study follow-up.
Active malignant tumor (tumors must be in remission for ≥ 6 months without maintenance chemotherapy and/or radiation)
Ongoing or recent history (within 6 months) of abnormal, severe, progressive, or uncontrolled hepatic, hematological, gastrointestinal, endocrine, pulmonary, cardiac, neurological, psychiatric, or cerebral diseases
Congenital immunodeficiencies
History of major surgery or severe trauma within the previous 3 months
Subjects who are actively being considered as candidates for solid organ transplantation or who may have a high likelihood of needing a solid organ transplant (ex. Progressive heart failure)
Females who are pregnant or breastfeeding or planning to become pregnant or breastfeed during the study (180 days)
Subjects who have known hypersensitivity or documented allergy to DMSO
Subjects who do not wish to or cannot comply with study procedures

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in New York?

Yes, this clinical trial (NCT06456073) has an active research site in New York, NY that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Chronic Anal Fissure Treatment Options in New York, NY

If you're searching for chronic anal fissure treatment options in New York, NY, this clinical trial (NCT06456073) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our New York research site is actively enrolling participants for this phase 1 clinical trial. You'll receive care from experienced chronic anal fissure specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all chronic anal fissure clinical trials near you to find additional studies recruiting in your area.

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