Is NCT06721143 recruiting in Miami, FL?

Yes, NCT06721143 is currently recruiting participants at its Miami, FL location. This chronic kidney disease stage 3 clinical trial is actively enrolling qualified participants.

How do I join the chronic kidney disease stage 3 clinical trial in Miami?

To join this clinical trial in Miami, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Miami clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Chronic Kidney Disease Stage 3 Clinical Trial in Miami, FL

About This Chronic Kidney Disease Stage 3 Study in Miami

The goal of this clinical trial is to learn about the safety (good or bad) of giving two AION-301 intravenous (IV) infusions, in adults with Stage 3 Chronic Kidney Disease (CKD). It will also help to learn if AION-301 reduces the symptoms of CKD and/or progression. The main questions it aims to answer are: * Do participants have medical problems (adverse events) after receiving two infusions of AION-301? * Do participants feel better (have reduced and/or delayed CKD symptoms)? * To learn about how AION-301 works in participants with CKD? Researchers will compare AION-301 to a placebo (a look-alike substance that contains no drug) to see if AION-301 works to treat Stage 3 CKD. Participants will: * Receive two infusions of AION-301 or placebo on two separate days (Day 0 and Day 4). * Receive oral vitamins at the clinic and to take at home for 90 days. * Visit the clinic for a minimum of 9 times, over 6 months for checkups and tests, but could be up to 12 times, over 24 months for checkups and tests.

Sponsor: AION Healthspan, Inc.

Who Can Participate

Inclusion Criteria

Participants are eligible to be included in the study only if all of the following criteria apply:

Patient is able to communicate well with the investigator, is capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol, understands all requirements of the study, and understands and signs the written ICF before any study-specific procedure.

Willing and able to comply with the scheduled visits and treatment plan.

Either biological sex

Participant must be 35 to 75 years of age inclusive, at the time of signing the informed consent.

Diagnosis of CKD stage 3, G3 (a and b): persistent eGFR between 30 and 59 mL/min/1.73 m² (at least 2 measures within that range in the preceding 3 months, including the one at screening visit), and persistent increased Albuminuria (at least 2 measures within 3 months, including 1 before screening and 1 at screening (criterion for increased Albuminuria at screening: ≥2 out of 3 repeat daily early morning samples at screening) (UACR ≥ 200 mg/g and \< than 5000 mg/g)

Treatment with maximum labelled or tolerated dose of a renin-angiotensin-aldosterone system (RAAS) blocking agent including an angiotensin converting enzyme (ACE) inhibitor or an angiotensin II receptor blocker (ARB), and SGLT2 inhibitors (SGLT2i) unless such treatment is contraindicated or not tolerated\*. Treatment dose must be stable for at least 3 months prior to the date of the screening. If a patient is on treatment with GLP-1 receptor agonist, he/she should be on a stable dose for at least 3 months before screening. \*Participants who are documented to be unable to take ACE inhibitors or ARBs or SGLT2i will be allowed to participate.

Female subjects must not be breastfeeding and must have no intention to become pregnant during the study, and she will be required to use at least two FDA approved birth control during the study. The FDA-approved and cleared methods for birth control are listed below:

Permanent Sterilization

Long-Acting Reversible Contraceptives (LARC)

Contraceptive Injection

Short-Acting Hormonal Methods

Barrier Methods

Emergency Contraception

Any male subject must agree to use contraceptives and not donate sperm during the study.

Contraceptive use by men and women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.

Exclusion Criteria

Participants are excluded from the study if any of the following criteria apply:

Prior transplant of any organ (including BM and stem cell transplant) or kidney transplant scheduled in the next 6 months.

Proteinuria\>5000 and or serum Albumin\< 2.5 g/dl.

Acute coronary syndrome, stroke or TIA or hospitalization for heart failure in previous 12 weeks or poorly controlled hypertension (≥160/100 mmHg at screening visit) or SBP\<90 at screening visit.

History of malignancy (except successfully treated squamous and basal cells skin carcinoma) within 5 years of screening.

History of atrial fibrillation (AF, AFib).

CKD due to genetic disorder.

History of systemic Autoimmune diseases like T1D, SLE or CKD caused by any autoimmune kidney disease.

Acute Kidney Injury (AKI) defined as increase in serum creatinine ≥1.5 times baseline in the previous 3 months or by presence of acute tubular injury in kidney biopsy in the previous 3 months.

Dialysis for acute renal failure within 12 weeks of screening visit.

Rapidly progressive kidney disease (eGFR reduction ≥ 30% over the last three months)

HbA1c ≥ 8.5%.

BMI ≥35 kg/m2.

Disorder of coagulation (including any history of thrombotic or thromboembolic disease) and/or long-term anti-coagulant therapy

History of Deep Vein Thrombosis (DVT)

History of Acute Pulmonary Embolism

History of solitary kidney.

On medications such as immunosuppressant, monoclonal antibodies, anabolic steroids, at the time of screening or in the previous 6 months and/or illicit drugs.

History of alcohol abuse or cigarette smoking in the previous 6 months.

Pregnancy or breast feeding at the time of screening, or with intention to become pregnant or breast-feeding during the course of the study, including the follow-up period.

History of liver disease, ALT and AST ≥3 x ULN, positive serology for Hepatitis B or Hepatitis C, HIV.

A significant medical history or abnormality at the physical exam that, in the judgment of the principal investigator, may interfere with the study.

Presence of any active infection, including COVID 19

Any clinically significant pulmonary disease

History of hypersensitivity to study drug and/or any of its excipients.

Close affiliation with the investigational site; for example, a close relative of the investigator, dependent person (for example employee or student of the investigational site).

Panel Reactive Antibodies (PRA) \>0% (positive)

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Miami?

Yes, this clinical trial (NCT06721143) has an active research site in Miami, FL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Chronic Kidney Disease Stage 3 Treatment Options in Miami, FL

If you're searching for chronic kidney disease stage 3 treatment options in Miami, FL, this clinical trial (NCT06721143) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Miami research site is actively enrolling participants for this clinical trial. You'll receive care from experienced chronic kidney disease stage 3 specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all chronic kidney disease stage 3 clinical trials near you to find additional studies recruiting in your area.

Chronic Kidney Disease Stage 3 Clinical Trial in Miami, FL

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