Boston, MANCT04500665Now EnrollingIRB Ready

Chronic Kidney Diseases Clinical Trial in Boston, MA

Access cutting-edge chronic kidney diseases treatment through this clinical trial at a research site in Boston. Study-provided care at no cost to qualified participants.

Sponsored by Brigham and Women's Hospital

Quick Self-Assessment

See if you qualify for this Boston location

Preparing your pre-screening questions…

Expert Care in Boston

Access chronic kidney diseases specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related chronic kidney diseases treatment provided free

Apply for This Boston Location

Check if you qualify for this chronic kidney diseases clinical trial in Boston, MA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Boston

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Boston site if eligible
  4. 4Begin participation

About This Chronic Kidney Diseases Study in Boston

This study is designed to determine the efficacy and safety of colchicine in patients with chronic kidney disease.

Sponsor: Brigham and Women's Hospital

Who Can Participate

Inclusion Criteria

Age 21 years to 80 years (inclusive)
eGFR of 15 to 75 mL/min per 1.73 m2
Urine albumin-to-creatinine ratio of greater than 30 mg/g
Use of maximally tolerated doses of an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker if urine albumin-to-creatinine ratio greater than 300 mg-g
Use of a sodium-glucose co-transporter-2 inhibitor if indicated in the opinion of the participant's primary clinician
Willing and able to provide written informed consent and to adhere to the study protocol B.

Exclusion Criteria

History of intolerance or allergy to colchicine
Hospitalization for any reason within the previous 30 days
Acute condition that requires emergent treatment in the opinion of a physician investigator
Stage C or D heart failure according to ACC-AHA criteria77
Left ventricular ejection fraction less than 40%
Symptomatic valvular heart disease
Congenital heart disease (corrected or uncorrected)
History of orthotopic heart transplant
Kidney failure, defined as kidney transplant recipient or requirement for hemodialysis or peritoneal dialysis
Worsening kidney function or acute kidney injury, defined as an increase in serum creatinine of greater than 0.3 mg/dL in the previous 30 days or 50% within the previous 7 days
Use of immunosuppressive or anti-inflammatory medications within the previous 30 days, with the exception of less than 5 days of non-steroidal anti-inflammatory drugs or corticosteroids for acute pain or other acute conditions that have since fully resolved provided that the last dose of non-steroid anti-inflammatory drug was at least 7 days before enrollment
Familial Mediterranean Fever, gout (unless no flare within the previous 12 months), pericarditis or other indications for colchicine treatment
Use of systemic antimicrobial therapy within the previous 30 days or active infection
History of respiratory illness that, in the opinion of a physician investigator, may increase the risk of pneumonia
Surgery within the previous 30 days or surgery planned to occur within the expected study period
Current malignancy or receipt of treatment for malignancy within the previous 1 year
Frailty or life-expectancy shortened by comorbidity such as cancer that would increase the participant's risk in the opinion of a physician investigator
Neutrophil count \< 2,000 cells/mm3
Platelet count \< 50,000 cells/mm3
Concomitant use of a P-gp inhibitor (e.g., cyclosporine, ranolazine, digoxin) and/or moderate-strong CYP3A4 inhibitor (e.g., clarithromycin, indinavir, itraconazole, ritonavir, nefazodone, diltiazem, verapamil, grapefruit juice, fluconazole)
Medications that may cause myopathy or rhabdomyolysis (i.e., simvastatin, gemfibrozil, fenofibrate) , a creatine kinase level after the run-in period that exceeds the upper limit of the normal laboratory reference range (if baseline was below the upper limit) or that increases by 50% or more from pre- to post-run-in
Moderate-severe hepatic disease (Child-Pugh B or C)
Pregnant or unwilling/unable to assure appropriate contraception
Breastfeeding

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT04500665) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Chronic Kidney Diseases Treatment Options in Boston, MA

If you're searching for chronic kidney diseases treatment options in Boston, MA, this clinical trial (NCT04500665) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced chronic kidney diseases specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all chronic kidney diseases clinical trials near you to find additional studies recruiting in your area.

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