Mayfield Heights, OHNCT07811869Now EnrollingIRB Ready

Chronic Pruritus of Unknown Origin Clinical Trial in Mayfield Heights, OH

Access cutting-edge chronic pruritus of unknown origin treatment through this phase 3 clinical trial at a research site in Mayfield Heights. Study-provided care at no cost to qualified participants.

Sponsored by Novartis Pharmaceuticals

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Expert Care in Mayfield Heights

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related chronic pruritus of unknown origin treatment provided free

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Check if you qualify for this chronic pruritus of unknown origin clinical trial in Mayfield Heights, OH

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Why Participate?

  • No-Cost Study Care

  • Local to Mayfield Heights

    Convenient for OH residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Mayfield Heights site if eligible
  4. 4Begin participation

About This Chronic Pruritus of Unknown Origin Study in Mayfield Heights

The purpose of this phase 3 study is to establish the efficacy, safety and tolerability of remibrutinib in adult participants with severe chronic pruritus of unknown origin (CPUO).

Sponsor: Novartis Pharmaceuticals

Who Can Participate

Inclusion Criteria

Participant must be ≥ 18 years of age, at the time of signing the informed consent.
Participants with chronic pruritus for at least 4 months prior to screening.
Chronic pruritus considered of unknown origin as assessed by the investigator at baseline (e.g., excluding chronic pruritus related to primary dermatological or systemic conditions, neuropathic or psychogenic origin or secondary to drugs or other allergen exposures).
Chronic pruritus must affect at least 2 of the following body areas: trunk, arms, or legs (cannot be unilateral and/or dermatomal in distribution).
Participants with ongoing, severe chronic pruritus despite the use of emollients and who are candidates for systemic therapy.
Participants must have severe itch defined by a WI-NRS ≥7 at screening; score scale ranges from 0 to 10; higher score indicates worse itch.
Participants must have an average WI-NRS ≥7 over the 7 days prior to randomization/baseline visit.
The average WI-NRS score over the preceding 7 days prior to the randomization/baseline visit will be calculated based on the daily WI-NRS scores (0-10).
Participants must have PGIS of pruritus scored as 3 "severe" at screening and baseline visits. Key

Exclusion Criteria

Any active skin conditions (e.g., atopic dermatitis, psoriasis, etc.) that may interfere with the assessment of CPUO.
Known systemic condition(s) or medication(s) that are considered by the investigator to be the primary cause of current pruritus.
Known or suspected infectious disease that is active, chronic or recurrent which precludes the participant from participating in the clinical trial as per Investigator´s assessment. These infectious diseases include but are not limited to opportunistic infections (e.g., tuberculosis, atypical mycobacterioses, listeriosis or aspergillosis) and/or known or suspected HIV infection.
History of malignancy of any organ system (other than localized basal cell carcinoma of the skin or in situ cervical cancer), treated or untreated, within the past 5 years, regardless of whether there is evidence of local recurrence or metastases.
Significant bleeding risk or coagulation disorders. History of gastrointestinal bleeding, e.g., in association with use of nonsteroidal anti-inflammatory drugs (NSAIDs), that was clinically relevant (e.g., where intervention was indicated or requiring hospitalization or blood transfusion). Requirement for anti-platelet medication, except for acetylsalicylic acid up to 100 mg/d or clopidogrel up to 75 mg/d. The use of dual anti-platelet therapy (e.g., acetylsalicylic acid + clopidogrel) is prohibited.
History or current hepatic disease, including but not limited to, acute or chronic hepatitis, cirrhosis or hepatic failure or aspartate aminotransferase (AST)/ alanine aminotransferase (ALT) levels of more than 1.5 x upper limit of normal (ULN) or International Normalized Ratio (INR) of more than 1.5 at screening.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Mayfield Heights?

Yes, this clinical trial (NCT07811869) has an active research site in Mayfield Heights, OH that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Chronic Pruritus of Unknown Origin Treatment Options in Mayfield Heights, OH

If you're searching for chronic pruritus of unknown origin treatment options in Mayfield Heights, OH, this clinical trial (NCT07811869) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Mayfield Heights research site is actively enrolling participants for this phase 3 clinical trial. You'll receive care from experienced chronic pruritus of unknown origin specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all chronic pruritus of unknown origin clinical trials near you to find additional studies recruiting in your area.

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