Birmingham, ALNCT03439865Now EnrollingIRB Ready

Chronic Rhinosinusitis (Diagnosis) Clinical Trial in Birmingham, AL

Access cutting-edge chronic rhinosinusitis (diagnosis) treatment through this early phase 1 clinical trial at a research site in Birmingham. Study-provided care at no cost to qualified participants.

Sponsored by University of Alabama at Birmingham

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Expert Care in Birmingham

Access chronic rhinosinusitis (diagnosis) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related chronic rhinosinusitis (diagnosis) treatment provided free

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Check if you qualify for this chronic rhinosinusitis (diagnosis) clinical trial in Birmingham, AL

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Why Participate?

  • No-Cost Study Care

  • Local to Birmingham

    Convenient for AL residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Birmingham site if eligible
  4. 4Begin participation

About This Chronic Rhinosinusitis (Diagnosis) Study in Birmingham

The purpose of this pilot study is to explore wither ivacaftor in refractory CRS patients will demonstrate safety and tolerability; restore CFTR-mediated Cl- secretions as measured by EDSPD testing; produce detectable improvements in validated measures of CRS including the SNOT-22 questionnaire, Lund-MacKay CT scan grading, and Lund-Kennedy endoscopic scores; and provide beneficial effects on readily measured markers of sinonasal inflammation and infection (IP-10, IL-8, and Pseudomonas CFUs).

Sponsor: University of Alabama at Birmingham

Who Can Participate

Inclusion Criteria

18 years of age
Patient has provided informed consent
Diagnosis of CRS made by one of the investigators
Standard of care CT scan with definitive demonstration of isolated or diffuse mucosal thickening, bone changes, and air fluid levels, obtained within 30 days of treatment
Positive culture of at least one gram negative bacteria (e.g. Pseudomonas, E. coli, Steenotrophomonas) within 30 days prior to testing
Previous surgery with (at least) exposed maxillary and ethmoid sinuses
Ability to perform EDSPD testing such that nasal cavity space and sinus openings are sufficient for catheter placement
Negative pregnancy test for females of childbearing potential within 72 hours of testing and start of study treatment

Exclusion Criteria

\< 18 years of age
Acute illness other than sinusitis within 2 weeks before start of study treatment that, in the opinion of the investigator, would preclude participation
Currently taking medications that are moderate or strong CP3A inhibitors
History of asthma attack requiring emergency room visit or treatment with oral steroids within 2 months prior to study treatment
History of solid organ or hematological transplantation
History of known immunodeficiency, autoimmune or granulomatous disorder
Serum creatinine \> 1.5x upper normal limit
Abnormal liver function, as defined by serum AST \> 2x upper normal limit, serum ALT \> 2x upper normal limit, Alkaline phosphatase \> 2x upper normal limit, Total bilirubin \> 2x upper normal limit
Women who are pregnant or breastfeeding

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Birmingham?

Yes, this clinical trial (NCT03439865) has an active research site in Birmingham, AL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Chronic Rhinosinusitis (Diagnosis) Treatment Options in Birmingham, AL

If you're searching for chronic rhinosinusitis (diagnosis) treatment options in Birmingham, AL, this clinical trial (NCT03439865) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Birmingham research site is actively enrolling participants for this early phase 1 clinical trial. You'll receive care from experienced chronic rhinosinusitis (diagnosis) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all chronic rhinosinusitis (diagnosis) clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Birmingham, AL