Charleston, SCNCT06824649Now EnrollingIRB Ready

Chronic Sinusitis Clinical Trial in Charleston, SC

Access cutting-edge chronic sinusitis treatment through this clinical trial at a research site in Charleston. Study-provided care at no cost to qualified participants.

Sponsored by Medical University of South Carolina

Quick Self-Assessment

See if you qualify for this Charleston location

Preparing your pre-screening questions…

Expert Care in Charleston

Access chronic sinusitis specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related chronic sinusitis treatment provided free

Apply for This Charleston Location

Check if you qualify for this chronic sinusitis clinical trial in Charleston, SC

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Charleston

    Convenient for SC residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Charleston site if eligible
  4. 4Begin participation

About This Chronic Sinusitis Study in Charleston

The prevalence of Chronic Sinusitis with Nasal Polyps (CRSwNP) in the United States is estimated at roughly 4%, which equates to over 13 million Americans. Until recently, the only medical treatment options available for patients with CRSwNP were corticosteroids, with surgery reserved for medical failure. The development of biologic medications over the last 5 years has revolutionized the treatment of CRSwNP. Three biologic medications have been FDA approved and available for the treatment of CRSwNP: dupilumab, omalizumab, and mepolizumab. However, data from the clinical trials for these drugs do not show universal improvement across all patients with CRSwNP. In fact, there is a wide range of outcomes for patients in these trials. The result is that clinicians have no way of knowing which specific biologic would be the best option for any given patient, nor do they know whether biomarkers can be used to predict response to biologics. It is hoped that findings from this study will inform whether any one biologic has superior outcomes to another and whether clinicians can identify patients at baseline who are most likely to improve on biologic therapy.

Sponsor: Medical University of South Carolina

Who Can Participate

Inclusion Criteria

Age \> 18 years
Confirmed diagnosis of chronic rhinosinusitis with nasal polyposis using ICAR-21 (International Consensus Statement 20215) criteria
Bilateral nasal polyposis visible on sinonasal endoscopy
Nasal polyp score \> 5
Baseline SNOT-22 total score \> 30
Patient elects biologic therapy for the management of CRSwNP
Capable of receiving all 3 biologic therapy medications.
Treatment with intranasal mometasone ≥200 μg. once daily (or equivalent of another intranasal corticosteroid) for 1-month prior to baseline visit.

Exclusion Criteria

Inability or unwillingness of a participant to give written informed consent or comply with study protocol
Endoscopic sinus surgery within 6-months preceding enrollment / randomization.
Oral corticosteroid use within 30-days preceding enrollment / randomization.
Serum IgE level outside the dosing range for omalizumab (i.e., \<30 IU/ml. or a weight-based dose with insufficient data to determine dose as per FDA dosing chart)
Comorbid atopic dermatitis, urticaria, or any other condition that would require a specific biologic per the standard of care.
Currently pregnant or plan to become pregnant within the 6 months after enrollment / randomization.
Any previous treatment with any of the 3 biologic medications.
Comorbid cystic fibrosis, CVID, or ciliary dyskinesia.
Comorbid systemic inflammatory disorders (e.g., GPA, EGPA, Sarcoidosis, SLE)
Past or current medical problems or findings from physical examination or laboratory testing that are not listed above, which, in the opinion of the investigator, may pose additional risks for participation in the study, may interfere with the participant's ability to comply with study requirements, or that may impact the quality or interpretation of the data obtained from the study.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Charleston?

Yes, this clinical trial (NCT06824649) has an active research site in Charleston, SC that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Chronic Sinusitis Treatment Options in Charleston, SC

If you're searching for chronic sinusitis treatment options in Charleston, SC, this clinical trial (NCT06824649) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Charleston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced chronic sinusitis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all chronic sinusitis clinical trials near you to find additional studies recruiting in your area.

More Interstitial Cystitis Trials in Charleston, SC

See all interstitial cystitis clinical trials recruiting in Charleston — not just this study.

Browse Interstitial Cystitis Trials in Charleston

Browse More Trials by Condition

Ready to Join in Charleston?

Take the first step toward participating in this groundbreaking clinical trial

Secure · Expert Care · Charleston, SC