Is NCT06617494 recruiting in Minneapolis, MN?

Yes, NCT06617494 is currently recruiting participants at its Minneapolis, MN location. This chronic temporomandibular disorders (tmd) clinical trial is actively enrolling qualified participants.

Is participation in this Minneapolis clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Chronic Temporomandibular Disorders (TMD) Clinical Trial in Minneapolis, MN

Q: How do I join the chronic temporomandibular disorders (tmd) clinical trial in Minneapolis?

To join this clinical trial in Minneapolis, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

About This Chronic Temporomandibular Disorders (TMD) Study in Minneapolis

Temporomandibular disorders (TMDs) involve a range of conditions with varied causes, affecting a large portion of the U.S. population and posing challenges for diagnosis and management, especially in chronic cases. Despite advances in understanding TMD pathophysiology, the role of central sensitization, particularly deficient endogenous pain inhibition, remains unclear. The conditioned pain modulation (CPM) test, used to assess pain inhibition in chronic TMD pain, has produced inconsistent results due to varying testing parameters. The proposed cross-sectional study will investigate the efficiency of endogenous pain inhibition in individuals with chronic TMD pain compared to controls by applying noxious and non-noxious stimuli to facial and non-facial sites. The findings aim to clarify the impact of weaker pain inhibition over the face, how the conditioning stimulus' painfulness affects inhibition and the relationship between pain inhibition and fluctuations in TMD pain intensity.

Sponsor: University of Minnesota

Who Can Participate

Inclusion Criteria

To be eligible to participate in this study, an individual must meet all the following criteria:

Provide informed consent, documented in a signed and dated form.

Will comply with all study procedures, including daily ratings filling before and after the in-person study visit, and be available for the study duration.

All participants of both genders between ages 18 to 74 years.

Cases and controls will be matched for age within ±5 years, and all participants must understand English commands to follow study procedures (e.g., during CPM testing). Pain-free controls:

Age matching (within ±5 years)

No previous diagnosis for the most common pain-related TMD as defined in the DC/TMD criteria (myalgia, arthralgia, headache attributed to TMD)

No significant orofacial pain (jaw pain, TMJ pain) in the past 3 months (""significant"" meaning 5 or more days in any month or any pain during the past month)

No report of significant pain in the last 3 months elsewhere in the body (""significant"" meaning 5 or more days in any month or any pain during the past month), e.g., low back pain, fibromyalgia, migraine headaches

Not meeting any of the most common pain-related TMD diagnoses as described in the DC/TMD criteria (myalgia, arthralgia, headache attributed to TMD) upon clinical exam following the DC/TMD protocol Chronic painful TMD cases:

Primary TMD case criteria: Myalgia (masticatory muscle pain) based on clinical exam following the DC/TMD protocol

Concurrent arthralgia (TMJ pain) and/or headache attributed to TMD allowed

Myofascial pain must meet the following criteria:

Onset \>3 months, occurring \>15 days/month on average for \>3 months

Minimum of 10 jaw pain episodes since onset, each lasting at least 30 minutes and no less than 2 hours within the day, OR unremitting."

Exclusion Criteria

An individual who meets any of the following criteria will be excluded from participation in this study:

Traumatic facial injury or surgery on the face/jaw, arms, or hands

Presence of pain related to dental and periodontal pathology

Has any of the following medical conditions by self-report:

Renal failure or dialysis

Heart disease (examples: uncontrolled arrhythmia or hypertension, cardiomyopathy) or heart failure

Non-allergic bronchospasm (chronic obstructive pulmonary disease and emphysema)

Diabetes (type I or II) that is not controlled with medication or diet

Hyperthyroidism

Uncontrolled seizures

Used any injection therapy (e.g., tender or trigger point injections, steroid injections), acupuncture, biofeedback, or TENS for managing facial/jaw pain within 2 weeks before the screening assessment.

If undergoing botulinum toxin injections in the head and neck area, must be 3 months since the last set of injections, and refrain from this treatment until study participation has ended

History of major depression or other major psychiatric disorder requiring inpatient hospitalization within the last 6 months before the screening assessment

History of treatment for drug or alcohol abuse within the last 12 months

Current pain medication use (e.g., opioids, ibuprofen, acetaminophen) that cannot be stopped \<24 hours before each study visit

Other conditions/diseases associated with altered pain perception: neurological or development disorders (dementia, autism spectrum disorder), neoplasm, multiple sclerosis, trigeminal neuralgia

Adults lacking the capacity to provide informed consent for themselves

Unable to understand instructions for sensory testing in English.

Thermal threshold for Pain-50 (pre-determined at the beginning of visit 1) is outside the temperature range of 40ºC to 49ºC

Inability to complete at least four daily ratings between the Informed consent, Pre-visit 1 procedures, and in-person visit 1

Lack of access to electronic devices with internet connection during the study participation

Anything that would place the individual at increased risk or preclude the individual's full compliance with study procedures or completion of the study. "

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Minneapolis?

Yes, this clinical trial (NCT06617494) has an active research site in Minneapolis, MN that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Chronic Temporomandibular Disorders (TMD) Treatment Options in Minneapolis, MN

If you're searching for chronic temporomandibular disorders (tmd) treatment options in Minneapolis, MN, this clinical trial (NCT06617494) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Minneapolis research site is actively enrolling participants for this clinical trial. You'll receive care from experienced chronic temporomandibular disorders (tmd) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all chronic temporomandibular disorders (tmd) clinical trials near you to find additional studies recruiting in your area.

Chronic Temporomandibular Disorders (TMD) Clinical Trial in Minneapolis, MN

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