NCT07162935 · University of Oklahoma
Cigar Legislation and Regulation in Tobacco for the Young (Project CLARITY)
(CLARITY)
What this study is about
This clinical trial will recruit young adults who currently use cigarillos and examine the smoking behavior and perceptions of different flavored cigarillos, product ingredients/additives impacting these perceptions, and simulated tobacco use outcomes (quitting, switching) in various policy scenarios where different types of flavors are available on the market.
View original scientific description
This clinical trial will recruit young adults who currently use cigarillos and examine the smoking behavior and perceptions of different flavored cigarillos, product ingredients/additives impacting these perceptions, and simulated tobacco use outcomes (quitting, switching) in various policy scenarios where different types of flavors are available on the market.
Interventions
OTHER
Cigarillo brand 1
Participants will be assessed on puffing behavior, subjective effects, and exhaled carbon monoxide when assigned to using one of three cigarillo brands. Additives and ingredients of the cigarillo used will also be assessed
OTHER
Cigarillo brand 2
Participants will be assessed on puffing behavior, subjective effects, and exhaled carbon monoxide when assigned to using one of three cigarillo brands. Additives and ingredients of the cigarillo used will also be assessed
OTHER
Cigarillo brand 3
Participants will be assessed on puffing behavior, subjective effects, and exhaled carbon monoxide when assigned to using one of three cigarillo brands. Additives and ingredients of the cigarillo used will also be assessed
Primary outcome measures
Puff number
Time frame: From enrollment to the end of the final smoking visit, approximately 2 weeks
Number of cigarillo puffs
Subjective reward from smoking
Time frame: From enrollment to the end of the final smoking visit, approximately 2 weeks
Self-reported reward from cigarillo smoking from a questionnaire. This scale has 5 questions with response options ranging from 1 - not at all to 7 - extremely. The score is averaged across the number of items. Higher ratings indicate greater psychological reward
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Ages 18 to 24
- Report past 30-day use of a cigarillo
- Ability to read English at least an 8th grade level
- No immediate plans to quit using tobacco
- At least 1 prior experience with a flavored tobacco product
- U.S. Citizen or permanent resident of the United States.
Exclusion criteria
- Current use of smoking cessation pharmacotherapy or nicotine replacement therapy;
- Pregnant, planning to become pregnant, or currently breastfeeding;
- Past or current clinically significant heart disease or hypertension, or other smoking-related disease that could preclude successful study completion;
- Inability to abstain from nicotine/tobacco products for at least 12 hours
- Unwillingness to use the research cigarillos in the lab
Where
- Oklahoma City, Oklahoma
- Morgantown, West Virginia
Collaborators
National Institute on Drug Abuse (NIDA), West Virginia University
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced May 11, 2026 · Source of record for eligibility and locations