NCT06668350 · University of Oklahoma
Attitudes and Perceptions Attitudes and Smoking Perceptions in the Real Environment -II
(ASPIRE-II)
What this study is about
This multi-method project will recruit young adults who currently use cigarillos and examine the effects of different flavored cigarillo types (concept, characterizing, tobacco) on three measures of tobacco product appeal: subjective effects (e.g., taste, enjoyment, satisfaction, reward), actual smoking behavior (e.g.
View original scientific description
This multi-method project will recruit young adults who currently use cigarillos and examine the effects of different flavored cigarillo types (concept, characterizing, tobacco) on three measures of tobacco product appeal: subjective effects (e.g., taste, enjoyment, satisfaction, reward), actual smoking behavior (e.g., number of puffs), and tobacco product purchases via a simulated experimental tobacco marketplace.
Interventions
OTHER
Smoking outcomes
Participants will be assessed on several smoking outcomes including puffing behavior, subjective effects, and exhaled carbon monoxide
Primary outcome measures
Puff volume
Time frame: From enrollment to the end of the study at 6 weeks
Volume of inhaled cigarillo puffs
Subjective effects from smoking
Time frame: From enrollment to the end of the study at 6 weeks
Self-reported reward from cigarillo smoking from a questionnaire. This scale has 5 questions with response options ranging from 1 - not at all to 7 - extremely. The score is averaged across the number of items. Higher ratings indicate greater psychological reward.
Exhaled carbon monoxide
Time frame: From enrollment to the end of the study at 6 weeks
Changes in exhaled carbon monoxide (CO boot) following cigarillo smoking
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Ages18 to 34
- Smoke a little cigar or cigarillo (LCCs) "some days" or "everyday" (verified by brand name of the product);
- Ability to read English at an 8th grade level or higher; and
- No immediate plans to quit using tobacco
- \> 1 prior experience, even 1 puff, with a flavored tobacco product
- U.S. Citizen or permanent resident of the United States.
Exclusion criteria
- Current use of nicotine replacement therapy (NRT) or stop smoking medication;
- Pregnant, planning to become pregnant, or currently breastfeeding;
- Past or current self-reported clinically significant heart disease or hypertension, or other smoking-related disease (by history) that preclude successful study completion;
- Inability to abstain from nicotine/tobacco products for at least 12 hours prior to lab sessions
- Report using the study cigarillo brand as their preferred brand (as this will likely unduly influence their perceptions)
- Unwillingness to use "untipped" (e.g., plastic or wood tip) little cigars/cigarillos.
Where
- Oklahoma City, Oklahoma
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Aug 17, 2025 · Source of record for eligibility and locations