Boston, MANCT06525623Now EnrollingIRB Ready

Cirrhosis, Liver Clinical Trial in Boston, MA

Access cutting-edge cirrhosis, liver treatment through this clinical trial at a research site in Boston. Study-provided care at no cost to qualified participants.

Sponsored by Massachusetts General Hospital

Quick Self-Assessment

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Expert Care in Boston

Access cirrhosis, liver specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related cirrhosis, liver treatment provided free

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Check if you qualify for this cirrhosis, liver clinical trial in Boston, MA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Boston

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Boston site if eligible
  4. 4Begin participation

About This Cirrhosis, Liver Study in Boston

The goal of this interventional study is to evaluate two strategies for how to provide intravenous (IV) fluids for treating patients with acute kidney injury (AKI) in cirrhosis. The main question it aims to answer is: what is the safety, efficacy, and feasibility of providing a recommendation to use a Volume Assessment Guidance Algorithm (VAGA) or give standard of care doses of IV albumin? Patients will be randomly assigned where their treating teams will receive a VAGA-based recommendation or a standard of care IV albumin recommendation.

Sponsor: Massachusetts General Hospital

Who Can Participate

Inclusion Criteria

Adult age 18 years or greater
Signed informed consent form (ICF) by any subject capable of giving consent, or, when the subject is not capable of giving consent, by their legally authorized representatives prior to initiation of any study procedures.
Admitted to the hospital
Diagnosis of decompensated cirrhosis (either prior to admission or new diagnosis on admission).
Presence of acute kidney injury (AKI) as defined by International Club of Ascites (ICA) criteria, defined as SCr increase of ≥0.3 mg/dL within 48 hours or ≥50% increase from baseline which is known or presumed to have occurred within the prior 7 days.

Exclusion Criteria

Requiring \>2 liters (L) supplemental oxygen at the time of screening.
In shock requiring vasopressors (vasoconstrictors for the treatment of AKI such as terlipressin, midodrine, and octreotide are allowed).
Allergy or other contraindication to IV albumin administration.
Death, liver transplant, or renal replacement therapy (RRT) expected within 48 hours.
Patient and/or legally authorized representative unable to provide informed consent.
Hepatic encephalopathy grade 3 or 4 at the time of screening.
Already received \>200 g albumin during admission at the time of screening.
Severe, active bleeding requiring 3 or more units of red blood cell transfusion in the 48 hours prior to screening.
Admission to the intensive care unit at the time of screening.
Mechanical ventilation at the time of screening.
Presence of New York Heart Association (NYHA) class 3-4 symptoms of congestive heart failure at the time of screening.
History of prior liver or kidney transplant.
Pregnant or nursing status
Any condition, in the opinion of the investigator, that could confound or interfere with the safe completion of study activities.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT06525623) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Cirrhosis, Liver Treatment Options in Boston, MA

If you're searching for cirrhosis, liver treatment options in Boston, MA, this clinical trial (NCT06525623) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced cirrhosis, liver specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all cirrhosis, liver clinical trials near you to find additional studies recruiting in your area.

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