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NCT05894967 · University of Wisconsin, Madison

Moderators and Mediators of Perceptual Learning

What this study is about

This is a research study about how training can impact performance on cognitive tasks. Participants are between 18 and 30 and 60 to 85 years of age, have normal (or corrected to normal) vision, and have no neurological conditions that would preclude their ability to complete computerized cognitive tasks. Up to 1140 participants will be on study for up to 8 weeks.

View original scientific description

This is a research study about how training can impact performance on cognitive tasks. Participants are between 18 and 30 and 60 to 85 years of age, have normal (or corrected to normal) vision, and have no neurological conditions that would preclude their ability to complete computerized cognitive tasks. Up to 1140 participants will be on study for up to 8 weeks.

Interventions

BEHAVIORAL

C1 - Standard Perceptual Learning (SPL)

Each trial starts with a fixation point (500ms) after which a Gabor (1° radius, at cut-off SF of 25% accuracy, estimated from Pre-Test CSF, at either 45° or 135°) appears for 128ms. The task is to indicate whether the Gabor was tilted left or right. Gabor contrast will be controlled by a 3/1 staircase (converging on approximately \~80% contrast threshold) across all training sessions.

BEHAVIORAL

C2 - Long Training (LT)

Will be the same as the SPL with the exception that each session in LT will be twice as long as in SPL.

BEHAVIORAL

C3 - Short Staircases (SS)

Will be largely the same as SPL with the only difference being a change to the adaptive procedure. SS will use so-called "short-staircases," which are initialized at 60% contrast with steps of .05 log units and employs a 3/1 staircase that after every 40 trials is reset (the "short" in "short-staircases") back to 60% contrast.

BEHAVIORAL

C4 - Mixed Difficulty (MD)

This condition will be identical to SPL with the exception that two staircases - one a 2/1 staircase producing difficulties centered around 60-70% accuracy, the other a 4/1 staircase producing difficulties centered around 85-95% accuracy - will be utilized to control the stimuli.

BEHAVIORAL

C5 - Noise Training (NT)

The NT condition will be the same as SPL with the exception that contrast thresholds will be estimated in 5-different levels of external noise (10%, 15%, 20%, 25%, 30%).

BEHAVIORAL

C6 - Training with Flankers (TWF)

TWF will be reasonably different from the standard SPL task. Here, on 50% of trials a target Gabor will be presented at either 45° or 135° (as in SPL) and will be flanked by two collinear Gabors. On the remaining 50% of trials, flankers will be present without a target. TWF is thus a yes/no detection task, which is necessary since the collinear flankers fully indicate the target orientation. In different 20-trial mini-blocks the flankers will appear either lambda, 1.5 lambda, or 2 lambda from the target (i.e., closer or further from the target) and target contrast will be controlled by a 3/1 staircase separately for each spacing.

BEHAVIORAL

C7 - Parafoveal Training (PT)

The PT condition is the baseline for C8-C11 (all of which involve parafoveally presented targets). In PT, we utilize the same task as in SPL, however, in PT, in addition to central training, targets will also appear in one of two peripheral locations (5° eccentricity; angles = 135° and 270°). The location of targets will be randomized trial-wise so as to discourage eye-movements and independent 3/1 staircases will be run at each location. By training only 2 peripheral locations we can measure the extent to which training gives rise to location transfer (e.g., in transfer tasks examining performance at 8 different locations - 2 trained locations and 6 untrained locations). Furthermore, training at the central location facilitates comparisons between PT and SPL.

BEHAVIORAL

C8 - Stimulus Variety (SV)

The base task for SV is the PT condition. However, SV employ 20 trial mini-blocks of different SFs (.75, 1.5, 3, 6, 12, 24 cpd) and locations (45°, 135°, 225°, 315° - i.e., more locations than PT, but not the full set tested in the transfer battery) with separate staircases for each SF and location. Orientations will also be drawn from a larger set (22.5°, 45°, 67.5° - for which participants respond "clockwise" and 112.5°, 135°, 157.5° - for which participants respond "counter-clockwise") and will vary on a trial-by-trial basis. This design holds-out 4 locations and 2 orientations to address transfer.

BEHAVIORAL

C8a - Complex Features (CF)

This is the same as C8, however we will use band-pass filtered stimuli similar to what has been done by a number of groups including Hussein et al.

BEHAVIORAL

C9 - Exogenous Attention Training (ExAT)

Stimuli will be presented in a similar manner as in PT. However, in ExAT, a 100% valid cue, a small black dot - 48ms duration with an 96ms SOA prior to stimulus onset - will appear above the target location on each trial.

BEHAVIORAL

C10 - Endogenous Attention Training (EnAT)

Stimuli will be presented in a similar manner as in PT. However, in EnAT, a 100% valid cue (letter UL, LR; standing for upper left and lower right, respectively) - 150ms duration with an 500ms SOA prior to stimulus onset - will appear at the fixation point.

BEHAVIORAL

C11 - Multisensory Facilitation (MF)

MF utilizes the same basic task structure as in ExEAT, however, rather than a visual cue, an auditory cue will be used (50ms, 1000hz tone with sound location determined by convolving sound with generic head-related transfer function, kemar large ears.

BEHAVIORAL

No Contact Control

While not a "training condition" one type of experience that could be part of a condition is a no contact control (i.e., where participants do no training activities over the same rough time span as for the other training tasks).

Primary outcome measures

Change in Near Transfer Task

Time frame: Baseline to Post-test 2, an average of 5-8 weeks

We will utilize an overarching task structure that allows us to assess learning on trained stimuli and transfer to untrained stimuli; locations, orientations, stimulus timings (e.g., we will assess contrast sensitivity for 6 different orientations). A trial begins with a fixation-point presented for 500ms. A target stimulus then appears for 128ms and then disappears (this timing was chosen to preclude participants making eye-movements to the stimuli). The participant is then required to respond by indicating the orientation of the stimulus (e.g., the major axis of a Gabor stimulus or gap-side of a C stimulus). In contrast tests, a staircase is run on the contrast of the target stimulus. In acuity tests, a staircase is run on the size of the stimulus. In parafoveal tests, stimuli are presented at 5° eccentricity.

Change in Transfer to Visual Search

Time frame: Baseline to Post-test 2, an average of 5-8 weeks

In a T/L annular visual-search task (1° stimuli, presented at 5° eccentricity at each of 8 evenly spaced locations), on each trial, 7 positions are filled with a distractor (upside-down Ls, half black and half white), while 1 position contains a target (rightside-up T that is either white or black). Stimuli are presented for 256ms and, after a variable SOA, a stimulus-mask (asterixis) appears. Participants report the color of the T. A 3/1 staircase controls the SOA of the mask (shorter SOAs = less time between stimulus and mask = more difficult). This task tests how training impacts processing time (i.e., time necessary to find and identify targets). Also, given that the same locations are used as in the parafoveal training, we can also estimate the extent to which transfer to visual search occurs and, if so, whether it is specific to the trained location.

Change in Transfer to Reading

Time frame: Baseline to Post-test 2, an average of 5-8 weeks

To understand visual performance related to reading, we employ the MNRead task, where participants read short sentences out-loud at various font-sizes. Dependent variables include reading speed, minimal text-size (another measure of acuity), and also critical print-size (text-size at which reading speed slows down).

Change in Transfer to Auditory Attention

Time frame: Baseline to Post-test 2, an average of 5-8 weeks

The procedure is based upon a speaker-on-speaker task where participants choose between 36 call signs (a color and number) spoken by a speaker. This task measures auditory thresholds for speech in the presence of other talkers, when all talkers are spatially collocated compared to when they are spatially offset.

Who can participate

This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.

Inclusion criteria

  • between18 and 30 years of age (younger cohort)
  • between 60 and 85 years of age (older cohort)
  • Corrected vision of 20/40 or better (as assessed with an eye chart)
  • No reported incidence of retinal pathology or neurological disease

Exclusion criteria

  • Corrected vision of 20/40 or worse
  • Evidence of retinal pathology or retinal disease

Where

  • Riverside, California
  • Boston, Massachusetts
  • Madison, Wisconsin

Collaborators

National Eye Institute (NEI)

Related conditions & keywords

Cognitive ChangeVision Training

Frequently asked questions

What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Data: ClinicalTrials.gov · synced Dec 15, 2025 · Source of record for eligibility and locations

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What participation can include

  • Study-related care provided by the research team
  • Close monitoring by medical professionals
  • Possible compensation for time and travel*
  • The option to withdraw at any time
  • Contributing to medical research that may help future patients

*Compensation varies by study. Confirm details with coordinator.

Typical next steps

  1. 1.Submit this form
  2. 2.Phone screening
  3. 3.In-person assessment if eligible
  4. 4.Begin participation

Looking for Cognitive Change Treatment in Riverside?

Join others in California exploring innovative treatment options through clinical research

Cognitive Change Treatment Options in Riverside, California

If you're searching for Cognitive Change treatment in Riverside, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in Riverside, Boston, Madison and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with Cognitive Change. All study-related care is provided at no cost to participants.

Local Sites
3 locations in California
Now Enrolling
Up to 1140 participants
Quick Start
Screening available now

Why Consider a Clinical Trial for Cognitive Change?

Potential Benefits

  • Access to new treatment approaches before public availability
  • Close monitoring by experienced medical professionals
  • Study-related care provided at no cost
  • Contribute to medical research for Cognitive Change

What to Expect

  • Initial screening to determine eligibility
  • Regular check-ups and monitoring visits
  • Possible compensation for time and travel
  • You can withdraw at any time

Frequently Asked Questions About This Cognitive Change Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT05894967. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.