NCT06223672 · Ohio State University
Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study
(EFFECT)
What this study is about
The proposed research is a randomly assigned crossover trial designed to assess changes in postprandial cognitive function and the gut-brain axis in adults with subjective cognitive complaints who consume 1 study snack per day for 1 week.
View original scientific description
The proposed research is a randomized crossover trial designed to assess changes in postprandial cognitive function and the gut-brain axis in adults with subjective cognitive complaints who consume 1 study snack per day for 1 week.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Subjective cognitive impairment
- BMI ≥30 kg/m2
- HbA1C \<6.5%
Exclusion criteria
- Diagnosis og cognitive impairment or dementia
- Montreal Cognitive Assessment (MoCA) score of \<26
- Current or previous diagnosis of Diabetes or use of diabetes medications
- Current diagnosis of or current treatment of cancer other than non-melanoma skin cancer
- Gastrointestinal diseases or disorders (including pancreatic and gastric bypass surgery) where consumption of the study foods would be contraindication or where the disease or disorder could negatively affect nutrient absorption and/or would prevent participants from tolerating the study foods
- Hyperthyroidism diagnosis
- Food Allergy or intolerances
- Any dietary restriction where consumption of the study foods, study meals/snack or meal challenge or any ingredient would be contraindicated
- Use of some oil supplements in the past 4 weeks prior to enrolling
- Pregnancy and lactation
- Inability to access veins for venipuncture
- Antibiotic use in the past month
- Psychostimulant or nootropic medication use
- Current use of supplements or medications for weight loss or following a weight loss program
- Severe or uncontrolled autoimmune diseases
- Current or previous diagnosis of severe kidney failure, liver cirrhosis and some pulmonary diseases
- Heart disease events (including stroke or heart attack) within last 3 months prior to enrollment
- Alcohol or drug abuse
Where
- Columbus, Ohio
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Apr 21, 2026 · Source of record for eligibility and locations