Milwaukee, WINCT06855433Now EnrollingIRB Ready

CPPD - Calcium Pyrophosphate Deposition Disease Clinical Trial in Milwaukee, WI

Access cutting-edge cppd - calcium pyrophosphate deposition disease treatment through this clinical trial at a research site in Milwaukee. Study-provided care at no cost to qualified participants.

Sponsored by Brigham and Women's Hospital

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This study follows strict safety protocols and ethical guidelines

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All study-related cppd - calcium pyrophosphate deposition disease treatment provided free

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Why Participate?

  • No-Cost Study Care

  • Local to Milwaukee

    Convenient for WI residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Milwaukee site if eligible
  4. 4Begin participation

About This CPPD - Calcium Pyrophosphate Deposition Disease Study in Milwaukee

The goal of this clinical trial is to learn if colchicine reduces levels of proteins indicating inflammation in the blood in individuals with calcium pyrophosphate deposition (CPPD) disease. The trial will also test the effect of colchicine on joint symptoms in CPPD disease. The main questions it aims to answer are: * Does colchicine reduce the level of interleukin 18 (IL-18) in the blood of individuals with CPPD disease? * Does colchicine reduce pain scores in individuals with CPPD disease? Researchers will compare colchicine once daily to a placebo (a look-alike pill that contains no drug) to see if colchicine works to treat CPPD disease. Participants will: * Take colchicine or a placebo every day for 6 months * Visit the clinic 3 times in 6 months for joint examinations, surveys, and blood tests. Each visit will last 2-3 hours. * Speak on the telephone with researchers for about 4 times over 6 months. Each phone call will last about 5 minutes.

Sponsor: Brigham and Women's Hospital

Who Can Participate

Inclusion Criteria

Provide written informed consent
Fulfill ACR/EULAR 2023 CPPD classification criteria
Acute or chronic joint inflammation currently or in the past 3 months, not attributable to another condition (Joint Inflammation defined as: At least 1 joint this is swollen, red, or warm to the touch; with or without corresponding tenderness)
Pain visual analog scale (pain VAS) \>=30 at screening

Exclusion Criteria

Age \<40 years
Chronic diarrhea
Gout, rheumatoid arthritis, psoriatic arthritis, or cirrhosis
Ongoing use of colchicine and unwilling to undergo a 30-day wash-out period (note: patients using colchicine at screening can enroll if they agree to a 30-day wash-out before randomization)
Pregnant or breast-feeding
Use of methotrexate, hydroxychloroquine, tocilizumab or canakinumab in the past 4 weeks
Use of anakinra, oral glucocorticoid, or intra-articular steroid in the past 1 week
Ongoing use of strong CYP3A4 inhibitors per FDA package insert for colchicine
Ongoing use of P-glycoprotein inhibitors per FDA package insert for colchicine
Known allergy to colchicine
Planned joint surgery in the next 6 months
CPPD clinical presentation isolated to Crowned Dens Syndrome with no additional peripheral joint involvement
Screening labs with any of the following:
Hemoglobin \< 9 g/dL
WBC \<3 x 10\^9/L
Platelets \<110 x10\^9/L
Creatinine clearance (CrCl) \<30 mL/min
ALT or AST \>3x upper limit of normal (ULN)
Patient is considered by investigator to be an unsuitable candidate for the study for any reason

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Milwaukee?

Yes, this clinical trial (NCT06855433) has an active research site in Milwaukee, WI that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

CPPD - Calcium Pyrophosphate Deposition Disease Treatment Options in Milwaukee, WI

If you're searching for cppd - calcium pyrophosphate deposition disease treatment options in Milwaukee, WI, this clinical trial (NCT06855433) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Milwaukee research site is actively enrolling participants for this clinical trial. You'll receive care from experienced cppd - calcium pyrophosphate deposition disease specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all cppd - calcium pyrophosphate deposition disease clinical trials near you to find additional studies recruiting in your area.

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