NCT07579455 · University of Oklahoma
Acute Pharmacokinetics of Create Wellness Gummies in Healthy Adults
What this study is about
The purpose of this study is to compare blood creatine levels following acute taken by mouth supplementation of Create Wellness creatine gummies to creatine monohydrate powder.
View original scientific description
The purpose of this study is to compare blood creatine levels following acute oral supplementation of Create Wellness creatine gummies to creatine monohydrate powder.
Interventions
DIETARY_SUPPLEMENT
Create Wellness Creatine Gummies
Create Wellness creatine gummies provide 4.5 grams of creatine monohydrate in a 3 gummy serving size.
DIETARY_SUPPLEMENT
Creatine Monohydrate Powder
4.5 grams of creatine monohydrate powder (Creapure®) dissolved in 240 mL of water.
Primary outcome measures
Peak plasma concentration (Cmax)
Time frame: 0 to 5-hours following supplementation.
Maximum plasma concentration observed.
Time to peak plasma concentration (Tmax)
Time frame: 0 to 5-hours following supplementation.
Time to reach maximum plasma concentration.
Area under the curve (AUC)
Time frame: 0 to 5-hours following supplementation.
Area under the plasma concentration curve.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Adults between the ages of 18-45 yrs
- Body mass index of \<35 kg/m2
- Recreationally active \[(≥30 minutes of moderate-intensity physical activity per week as defined by the International Physical Activity Questionnaire (IPAQ)\]
- Healthy and free from major diseases as determined from screening call and health history questionnaire.
- Agrees to complete pre-assessment guidelines (8-hour fast from caloric foods and beverages, 24-hour abstention from vigorous physical activity, caffeine, alcohol, and tobacco).
Exclusion criteria
- Chronic kidney disease, liver disease, chronic obstructive pulmonary disease, or cancer.
- Currently using medications that may directly impact the primary outcomes including: diuretics and corticosteroids).
- Currently using creatine monohydrate
- Severely impaired hearing or speech or inability to speak English.
Where
- Norman, Oklahoma
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced May 28, 2026 · Source of record for eligibility and locations