NCT06815367 · University of Southern California
Pneumatic Compression vs Blood Flow Restriction for Muscle Recovery
What this study is about
Both BFR and intermittent pneumatic compression are purported to decrease symptoms associated with exercise induced muscle damage (EIMD) that cause delayed onset muscle soreness (DOMS). Blood flow restriction relies on applying pressurized cuffs to the most proximal portion of the limb. Another form of recovery often relied upon is pneumatic compression.
View original scientific description
Both BFR and intermittent pneumatic compression are purported to decrease symptoms associated with exercise induced muscle damage (EIMD) that cause delayed onset muscle soreness (DOMS). Blood flow restriction relies on applying pressurized cuffs to the most proximal portion of the limb. Another form of recovery often relied upon is pneumatic compression. The mechanism by which pneumatic compression works is similar to that of a massage, whereby the device progressively increases the pressure on a portion of the limb before releasing and moving further up the limb.The purpose of this study is determine whether BFR or pneumatic compression can be used to decreased DOMS which may indicate enhanced recovery.
Interventions
DEVICE
Pneumatic Compression
Following downhill running protocol, participants will complete 20 minutes of pneumatic compression at 100 mmHg.
DEVICE
Blood Flow Restriction
Following the downhill running protocol, participants will complete 4 rounds of treatment: 3 minutes at 100% resting limb occlusion pressure, 2 minutes of 0% resting limb occlusion pressure.
Primary outcome measures
Counter Movement Jump Height
Time frame: Immediately before and immediately after exercise, immediately after treatment, 24-hours post treatment.
Participants will be asked to complete three consecutive counter movement jumps with hands on hips. The CMJ will be used as an indirect measure of muscle function.
Maximal Voluntary Isometric Contraction
Time frame: Immediately before and immediately after exercise, immediately after treatment, 24-hours post treatment.
Participants will be asked to complete an MVIC to assess muscle function.
Sedentary delayed onset muscle soreness
Time frame: Immediately before and immediately after exercise, immediately after treatment, 24-hours post treatment.
Using a visual analog scale, participants will be asked to rate their level of soreness while at rest.
Active delayed onset muscle soreness
Time frame: Using a visual analog scale, participants will be asked to rate their level of soreness while at rest.
Using a visual analog scale, participants will be asked to rate their level of soreness while completing a wall sit.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- 18-30 years of age
- Recreationally active population
- Women should be on a form of hormonal contraception.
- No current musculoskeletal injuries or pathologies
- Must answer "yes" to all PAR-Q questions.
Exclusion criteria
- Individuals that routinely train trail running
- Discomfort when running
- Deep vein thrombosis
- Blood clots
- Cancerous lesions
- Sensory or mental impairment
- Unstable fractures
- Acute pulmonary edema
- Acute thrombophlebitis
- Acute congestive cardiac failure
- Acute infections
- Episodes of pulmonary embolism
- Wounds, lesions, infection, or tumors
- Bone fractures or dislocations
- Increased venous and lymphatic return
- Answers "no" to any of the PAR-Q screening questions
Where
- Los Angeles, California
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Mar 30, 2026 · Source of record for eligibility and locations