East Providence, RINCT07227454Now EnrollingIRB Ready

Depressive Disorder, Major Clinical Trial in East Providence, RI

Access cutting-edge depressive disorder, major treatment through this clinical trial at a research site in East Providence. Study-provided care at no cost to qualified participants.

Sponsored by Janssen Research & Development, LLC

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Expert Care in East Providence

Access depressive disorder, major specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related depressive disorder, major treatment provided free

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Check if you qualify for this depressive disorder, major clinical trial in East Providence, RI

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to East Providence

    Convenient for RI residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit East Providence site if eligible
  4. 4Begin participation

About This Depressive Disorder, Major Study in East Providence

The purpose of this study is to evaluate how well JNJ-54135419 works (efficacy) in addition to comprehensive standard of care (SoC) in rapidly reducing the symptoms of major depressive disorder (MDD, a mental disorder characterized by a persistent feeling of sadness and loss of interest in activities) as compared with psychoactive placebo (does not contain JNJ-54135419) plus SoC in adolescent participants with acute suicidal ideation or behavior.

Sponsor: Janssen Research & Development, LLC

Who Can Participate

Inclusion Criteria

Must meet diagnostic and statistical manual of mental disorders (5th edition) (DSM-5) diagnostic criteria for major depressive disorder (MDD) based upon clinical assessment and confirmed by the mini-international neuropsychiatric interview for children and adolescents (MINI-KID)
Must have a clinical global impression - severity of suicidality - revised (CGI-SS-R) score of "Markedly" or greater (that is, greater than or equal to \[\>=\] 4) at both screening and baseline (predose) visits
Must have a children's depression rating scale - revised (CDRS-R) total score \>= 58 at baseline (predose)
In the physician's opinion, acute psychiatric hospitalization is clinically warranted due to subject's acute suicidality
Must be medically stable based on physical examination, medical history, vital signs, and 12-lead electrocardiogram (ECG) performed at screening

Exclusion Criteria

Participant has a current DSM-5 diagnosis of bipolar (or related disorders), intellectual disability, autism spectrum disorder, conduct disorder, oppositional defiant disorder
Participant currently meets DSM-5 criteria for borderline personality disorder
Participant has a current or prior DSM-5 diagnosis of a psychotic disorder, or MDD with psychosis
Participant has a history of seizure disorder
Participant has known allergies, hypersensitivity, intolerance or contraindications to midazolam, esketamine or ketamine, or their excipients

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in East Providence?

Yes, this clinical trial (NCT07227454) has an active research site in East Providence, RI that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Depressive Disorder, Major Treatment Options in East Providence, RI

If you're searching for depressive disorder, major treatment options in East Providence, RI, this clinical trial (NCT07227454) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our East Providence research site is actively enrolling participants for this clinical trial. You'll receive care from experienced depressive disorder, major specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

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Secure · Expert Care · East Providence, RI