Costa Mesa, CANCT07876908Now EnrollingIRB Ready

Depressive Disorder, Treatment-Resistant Clinical Trial in Costa Mesa, CA

Access cutting-edge depressive disorder, treatment-resistant treatment through this clinical trial at a research site in Costa Mesa. Study-provided care at no cost to qualified participants.

Sponsored by BrainHealth Solutions, Inc.

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Expert Care in Costa Mesa

Access depressive disorder, treatment-resistant specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related depressive disorder, treatment-resistant treatment provided free

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Why Participate?

  • No-Cost Study Care

  • Local to Costa Mesa

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Costa Mesa site if eligible
  4. 4Begin participation

About This Depressive Disorder, Treatment-Resistant Study in Costa Mesa

The goal of this clinical trial is to learn whether Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT®), a type of transcranial magnetic stimulation (TMS), is safe and may improve memory and thinking in adults aged 65 or older with treatment-resistant depression and memory concerns. Researchers will also study whether SAINT® improves depression symptoms. The main questions it aims to answer are: * Does SAINT® improve memory and thinking five days after treatment? * Does SAINT® improve depression symptoms and overall well-being? * Do changes in memory, mood, or daily activities last for up to one year? * What side effects or safety concerns occur during and after treatment? All participants will receive SAINT® treatment. There is no placebo group. Participants will: * Complete memory, mood, and health assessments and have an MRI scan * Receive 10 TMS sessions each day for 5 days in a row * Return for follow-up visits for up to 12 months Researchers will track changes in memory, mood, daily activities, and side effects.

Sponsor: BrainHealth Solutions, Inc.

Who Can Participate

Inclusion Criteria

Age 65 years or older
Diagnosis of treatment-resistant depression
Current depressive symptoms, with a Montgomery-Asberg Depression Rating Scale (MADRS) score of 20 or higher
A memory concern reported by the participant or caregiver
A Mini-Mental State Examination (MMSE) score between 10 and 28
Able to understand the study, provide written informed consent, and complete study assessments
Determined by an independent treating clinician to be an appropriate candidate for accelerated SAINT treatment, consisting of 10 treatment sessions per day for 5 consecutive days
Completed an amyloid PET scan and/or Lumipulse G pTau217/Amyloid 1-42 blood test as part of usual medical care within 6 months before the baseline visit
Health insurance coverage confirmed for rTMS/SAINT treatment for treatment-resistant depression
Willing to follow study requirements, including medication restrictions and study visits

Exclusion Criteria

Unable or unwilling to use an acceptable method of birth control during the 5-day treatment period and for 30 days afterward, if of childbearing potential or sexually active with a partner of childbearing potential
Non-removable metal or an implanted medical device in or near the head that is not safe for transcranial magnetic stimulation or magnetic resonance imaging, such as a cochlear implant, aneurysm clip, stent, or metal fragment
An implanted neurostimulator in or near the head, such as a deep brain stimulator or vagus nerve stimulator
History of epilepsy or a seizure disorder, except for isolated febrile seizures during childhood
A brain condition that may increase seizure risk, such as prior brain surgery, skull defect, stroke-related brain disease, or brain tumor
Any other contraindication to transcranial magnetic stimulation listed in the device instructions for use that the study doctor believes would increase risk
A clinically significant abnormal magnetic resonance imaging (MRI) result
A current psychiatric diagnosis other than major depressive disorder that could affect safe participation, including schizophrenia, schizoaffective disorder, bipolar disorder, or post-traumatic stress disorder
A diagnosis of borderline, paranoid, histrionic, schizotypal, schizoid, or antisocial personality disorder
Substance abuse or dependence within the past year, including alcohol or benzodiazepines, except caffeine or nicotine
High current risk of suicide or a suicide attempt within the past 6 months
A serious or unstable medical condition that could make participation unsafe or affect interpretation of the study results
Resting heart rate below 40 beats per minute or above 110 beats per minute at the clinic visit
Use of a medication or procedure that the study doctor determines may significantly interfere with transcranial magnetic stimulation treatment
Any other condition that, in the study doctor's judgment, would make participation unsafe or prevent completion of the study requirements

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Costa Mesa?

Yes, this clinical trial (NCT07876908) has an active research site in Costa Mesa, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Depressive Disorder, Treatment-Resistant Treatment Options in Costa Mesa, CA

If you're searching for depressive disorder, treatment-resistant treatment options in Costa Mesa, CA, this clinical trial (NCT07876908) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Costa Mesa research site is actively enrolling participants for this clinical trial. You'll receive care from experienced depressive disorder, treatment-resistant specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all depressive disorder, treatment-resistant clinical trials near you to find additional studies recruiting in your area.

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