Orlando, FLNCT05478707Now EnrollingIRB Ready

Diabetes Mellitus, Type 1 Clinical Trial in Orlando, FL

Access cutting-edge diabetes mellitus, type 1 treatment through this phase 2 clinical trial at a research site in Orlando. Study-provided care at no cost to qualified participants.

Sponsored by AdventHealth Translational Research Institute

Quick Self-Assessment

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Expert Care in Orlando

Access diabetes mellitus, type 1 specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related diabetes mellitus, type 1 treatment provided free

Apply for This Orlando Location

Check if you qualify for this diabetes mellitus, type 1 clinical trial in Orlando, FL

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Orlando

    Convenient for FL residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Orlando site if eligible
  4. 4Begin participation

About This Diabetes Mellitus, Type 1 Study in Orlando

The investigators will test the hypothesis that, in adults with type 1 diabetes (T1D), glucagon-like peptide-1 receptor agonism (GLP-1RA, i.e. dulaglutide) enhances insulin-mediated skeletal muscle microvascular perfusion via attenuating endothelial oxidative stress and thereby improving endothelial function.

Sponsor: AdventHealth Translational Research Institute

Who Can Participate

Inclusion Criteria

History of type 1 diabetes, duration \> 5 years
Age 18-40 years
HbA1c \< 8.5%
BMI 19-34.9 kg/m2
Using insulin for diabetes treatment only (multiple daily injections or insulin pump with or without sensor augmentation)
On stable regimen of non-diabetic medications for the last 6 months
All screening labs within normal limits or not clinically significant - English or Spanish speaking

Exclusion Criteria

Pregnancy or currently breastfeeding
Smoking history within 6 months
History of microvascular (microalbuminuria, retinopathy, neuropathy) or macrovascular diabetes complications (coronary artery disease, stroke, peripheral vascular disease) as well as clinically significant cardiac arrhythmias or conduction disorders
Taking vasoactive medications (i.e. calcium channel blockers, angiotensin-converting enzyme or renin inhibitors, angiotensin-receptor blockers, nitrates, alpha-blockers).
Known hypersensitivity to perflutren (contained in Definity© contrast)
Screening O2 saturation \<90%
Musculoskeletal condition preventing participation in exercise testing or exercise training
Acute or unstable disease other than T1D
Hypoglycemia unawareness
History of gastroparesis, severe gastroesophageal reflux, pancreatitis, personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2
Anemia (hemoglobin \<12 g/dL in women, hemoglobin \<13 g/dL in men), eosinophilia (absolute eosinophil count \>500 cells/microliter) leukopenia (total white blood cells \<4,000 cells/microliter)
Diabetic ketoacidosis (DKA) on presentation to screening visits or study admission days
Hospital admission for DKA within 1 year

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Orlando?

Yes, this clinical trial (NCT05478707) has an active research site in Orlando, FL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Diabetes Mellitus, Type 1 Treatment Options in Orlando, FL

If you're searching for diabetes mellitus, type 1 treatment options in Orlando, FL, this clinical trial (NCT05478707) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Orlando research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced diabetes mellitus, type 1 specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all diabetes mellitus, type 1 clinical trials near you to find additional studies recruiting in your area.

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