NCT06366399 · University of Utah
The Acute T-Rex (Timing of Resistance Exercise) Study
What this study is about
The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomly assigned cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting.
View original scientific description
The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur \~1.5 hours after habitual wake, and PM exercise will occur \~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Men and women, all ethnicities, aged 50-74 years
- BMI ≥25 kg/m² and \<45 kg/m²
- Weight stable (less than 5% change in the past 6 months)
- Generally healthy individuals
- Not meeting recommended activity guidelines for aerobic or resistance exercise
Exclusion criteria
- Uncontrolled cardiovascular, metabolic, renal, or pulmonary disease
- Cancer treatment in the past 5 years
- Untreated thyroid disease or other medical conditions affecting weight or energy metabolism
- Current use of weight loss medication or other medications likely to impact energy balance
- Bariatric surgery or extensive bowel resection in the past 2 years
- Current or recent history (past 2 years) of eating disorder
- Diagnosis of insomnia, sleep apnea, or other sleep and circadian disorders
- Non-English speaking
- HbA1c \>6.5%
Where
- Salt Lake City, Utah
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Apr 3, 2025 · Source of record for eligibility and locations