NCT04505618 · Johns Hopkins University
Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease
(OCTA-RVD)
What this study is about
This study will perform a forward-looking, longitudinal analysis of clinical and imaging findings from normal controls and subjects with retinal vascular disease to better define the diagnostic imaging criteria that signify change in disease stage. This includes disease progression in early stages of disease or disease regression with appropriate standard-of-care treatment.
View original scientific description
This study will perform a prospective, longitudinal analysis of clinical and imaging findings from normal controls and subjects with retinal vascular disease to better define the diagnostic imaging criteria that signify change in disease stage. This includes disease progression in early stages of disease or disease regression with appropriate standard-of-care treatment.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Both subjects with diseases and controls:
- Children (age\<18)
- Pregnant females
- Developmentally delayed subjects
- Subjects unable to provide informed consent
- Inability to cooperate with tests and study instructions
- Images with motion artifact or signal strength \< 7
- History of glaucoma
- History of age-related macular degeneration
- History of any visually significant eye disease
- History of proliferative diabetic retinopathy
- History of any inflammatory disease
- History of heart disease
- History of thyroid disease.
- Additional criteria for controls:
- History of any type of Diabetes Mellitus
- History of any type of Hypertension
Exclusion criteria
- Both subjects with diseases and controls:
- Children (age\<18)
- Pregnant females
- Developmentally delayed subjects
- Subjects unable to provide informed consent
- Inability to cooperate with tests and study instructions
- Images with motion artifact or signal strength \< 7
- History of glaucoma
- History of age-related macular degeneration
- History of any visually significant eye disease
- History of proliferative diabetic retinopathy
- History of any inflammatory disease
- History of heart disease
- History of thyroid disease.
- Additional criteria for controls:
- History of any type of Diabetes Mellitus
- History of any type of Hypertension
Where
- Baltimore, Maryland
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jun 17, 2026 · Source of record for eligibility and locations