NCT05477277 · Mayo Clinic
Adverse Outcomes and Mortality in Liver Transplant
What this study is about
forward-looking natural history pilot study to explore the link between muscle composition using an MRI-based Muscle Assessment Score (MAsS) and adverse outcomes in liver transplant candidates.
View original scientific description
Prospective natural history pilot study to explore the link between muscle composition using an MRI-based Muscle Assessment Score (MAsS) and adverse outcomes in liver transplant candidates.
Interventions
DIAGNOSTIC_TEST
MAsS
Add MAsS to standard of care MRI scan
Primary outcome measures
Muscle assessment score (MAsS)
Time frame: 1 year
The MAsS is a composite score of muscle fat index (% of muscle fat normalized to sex, weight in kg and height in meters) and muscle volume index (muscle volume in liters normalized to patient sex, height in meters and weight in kg)
Adverse outcomes
Time frame: 1 year
Number of pre- and post-transplant inpatient days
Adverse outcomes
Time frame: 1 year
Number of pre- and post-transplant ICU days
Adverse outcomes
Time frame: 1 year
Number of days alive outside of the hospital in the first year after liver transplant
Adverse outcomes
Time frame: 1 year
Mortality within the first year after liver transplant
MAsS changes while waiting for liver transplant
Time frame: 1 year
In patients who remain on the waitlist, serial MAsS measurements (see Outcome 1) will be taken and changes over time will be assessed
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- All patients with end-stage liver disease undergoing evaluation for liver transplantation
- Patient clinically indicated for MRI during transplant candidacy evaluation
Exclusion criteria
- 1\. Contra indication to MRI
Where
- Phoenix, Arizona
Collaborators
Amra Medical AB
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Aug 15, 2025 · Source of record for eligibility and locations