NCT06847685 · Johns Hopkins University
Mechanisms of Uterine Fluid Absorption During Early Pregnancy ( ELF Study)
What this study is about
The researchers are evaluating mechanisms of uterine fluid absorption during early pregnancy
View original scientific description
The researchers are evaluating mechanisms of uterine fluid absorption during early pregnancy
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Subject must be a healthy woman between the ages of 18 and 45 years.
- Women with diagnosed endometriosis or infertility (cases).
- Women without a diagnosis of endometriosis or infertility (controls).
- Subject must have regular menstrual cycles.
- Subject must have a body mass index (BMI) between 18 and 40.
- Subject must be or have been sexually active or have had a previous vaginal exam that used a speculum.
- Subject must be able to understand and provide consent to procedures and use/disclosure of protected health information.
- No history of Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, hepatitis B, and HIV.
- For IVF study subjects, a minimum endometrial thickness of 7mm at the time of sample collection.
Exclusion criteria
- Pregnant women.
- Study subjects with endometrial cancer.
- Study subjects with a history of endometrial ablation.
- Study subjects with undiagnosed uterine bleeding.
- Women with reproductive diseases that affect the endometrium (such as fibroids or uterine polyps that distort endometrial cavity).
- Study subjects with an intrauterine device (IUD).
Where
- Athens, Georgia
- Baltimore, Maryland
- Piscataway, New Jersey
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Mar 9, 2026 · Source of record for eligibility and locations