Philadelphia, PANCT01241305Now EnrollingIRB Ready

Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) Clinical Trial in Philadelphia, PA

Access cutting-edge eosinophilic granulomatosis with polyangiitis (churg-strauss) treatment through this clinical trial at a research site in Philadelphia. Study-provided care at no cost to qualified participants.

Sponsored by University of Pennsylvania

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Expert Care in Philadelphia

Access eosinophilic granulomatosis with polyangiitis (churg-strauss) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related eosinophilic granulomatosis with polyangiitis (churg-strauss) treatment provided free

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Check if you qualify for this eosinophilic granulomatosis with polyangiitis (churg-strauss) clinical trial in Philadelphia, PA

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Why Participate?

  • No-Cost Study Care

  • Local to Philadelphia

    Convenient for PA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Philadelphia site if eligible
  4. 4Begin participation

About This Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) Study in Philadelphia

The purpose of this study is to identify genes that increase the risk of developing vasculitis, a group of severe diseases that feature inflammation of blood vessels. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.

Sponsor: University of Pennsylvania

Who Can Participate

Inclusion Criteria

1\. Diagnostic criteria for Giant Cell Arteritis Age at disease onset \>50 years (required)
New onset or new type of localized pain in the head
Temporal artery abnormality (i.e. temporal artery tenderness to palpation or decreased pulsation, unrelated to arteriosclerosis of cervical arteries)
ESR of \>40mm in the first hour by the Westergren method
Abnormal artery biopsy (i.e. temporal artery biopsy showing vasculitis characterized by a predominance of mononuclear cell infiltration or granulomatous inflammation, usually with multinucleated giant cells)
Large Vessel Vasculitis (LVV) by angiogram or biopsy not explained by something else Inclusion Criteria: 2\. Diagnostic criteria for Takayasu's Arteritis
Age at disease onset \<50 years
Claudication of extremities
Decreased brachial artery pulse (one or both arteries)
Blood pressure difference of \>10mm Hg between the arms
Bruit over subclavian arteries or aorta
Arteriogram abnormalities compatible with TAK (includes conventional dye angiography or MR angiography or CT angiography) Inclusion Criteria: 3\. Diagnostic criteria for Polyarteritis Nodosa Major criteria (not explained by other causes) felt by investigator to be due to vasculitis
Arteriographic abnormality
Presence of granulocyte or mixed leukocyte infiltrate in an arterial wall on biopsy
Mononeuropathy or polyneuropathy Minor criteria (not explained by other causes) felt by investigator to be due to vasculitis
Weight loss \> 4 kg
Livedo reticularis, cutaneous ulcerations, or skin nodules
Testicular pain or tenderness
Diastolic blood pressure \> 90 mm Hg
Elevated BUN or serum creatinine levels
Ischemic abdominal pain Isolated cutaneous Polyarteritis Nodosa 1. Biopsy-proven cutaneous PAN Inclusion Criteria: 4\. Diagnostic criteria for Granulomatosis with Polyangiitis (Wegener's) (GPA) and Microscopic Polyangitis (MPA)
Diagnosis of GPA or MPA. Widely accepted diagnostic criteria, as opposed to classification criteria or definitions, have not been developed for GPA \& MPA.
For diagnosis of GPA meets at least 2 of the following 5 modified ACR criteria:
Nasal or oral inflammation with oral ulcers or nasal discharge with pus or blood
Abnormal chest radiograph with nodules, fixed infiltrates, or cavities
Urinary sediment with microhematuria or red cell casts
Granulomatous inflammation within the wall of an artery or in the perivascular area on biopsy
Antineutrophil cytoplasmic antibody (ANCA) positive by enzyme immunoassay for either PR3- or MPO-ANCA
For diagnosis of MPA, meets the Chapel Hill Consensus Conference Definition for MPA:
Necrotizing vasculitis, with few or no immune deposits, that affects small vessels (i.e., capillaries, venules, arterioles)
Necrotizing arteritis involving small- and medium-sized arteries may be present
Necrotizing glomerulonephritis is very common
Pulmonary capillaritis often occurs Inclusion Criteria: 5\. Diagnostic criteria for Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss)
Peak peripheral blood eosinophilia of \>10% of total WBC
Peripheral neuropathy attributable to vasculitis
Transient pulmonary infiltrates on chest imaging studies
Paranasal sinus abnormalities or nasal polyposis
Eosinophilic inflammation on tissue biopsy If patients have 4 of the above 6 criteria but lack clearcut documentation of small vessel vasculitis, they are also eligible for enrollment. General

Exclusion Criteria

Inability to give informed consent and to sign the consent form
Enrolled in VCRC protocols 5502, 5503, 5504, 5505, 5506, 5522, or 5523
Unwilling to provide blood for DNA collection

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Philadelphia?

Yes, this clinical trial (NCT01241305) has an active research site in Philadelphia, PA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) Treatment Options in Philadelphia, PA

If you're searching for eosinophilic granulomatosis with polyangiitis (churg-strauss) treatment options in Philadelphia, PA, this clinical trial (NCT01241305) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Philadelphia research site is actively enrolling participants for this clinical trial. You'll receive care from experienced eosinophilic granulomatosis with polyangiitis (churg-strauss) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all eosinophilic granulomatosis with polyangiitis (churg-strauss) clinical trials near you to find additional studies recruiting in your area.

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