Is NCT04308330 recruiting in Valhalla, NY?

Yes, NCT04308330 is currently recruiting participants at its Valhalla, NY location. This ewing sarcoma clinical trial is actively enrolling qualified participants.

How do I join the ewing sarcoma clinical trial in Valhalla?

To join this clinical trial in Valhalla, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Valhalla clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Ewing Sarcoma Clinical Trial in Valhalla, NY

About This Ewing Sarcoma Study in Valhalla

Investigators are testing new experimental drug combinations such as the combination of vorinostat, vincristine, irinotecan, and temozolomide in the hopes of finding a drug that may be effective against tumors that have come back or that have not responded to standard therapy. The goals of this study are: * To find the highest safe dose of vorinostat that can be given together with vincristine, irinotecan, and temozolomide without causing severe side effects; * To learn what kind of side effects this four drug combination can cause; * To learn about the effects of vorinostat and the combination of vorinostat, vincristine, irinotecan, and temozolomide on specific molecules in tumor cells; * To determine whether the combination of vorinosat, vincristine, irinotecan, and temozolomide is a beneficial treatment.

Sponsor: New York Medical College

Who Can Participate

Inclusion Criteria

Age: Patients must be less than or equal to 1 year and less than or equal to 30 years of age at initiation of protocol therapy.

Diagnosis: Patients must have a confirmed histologic diagnosis of a relapsed or refractory solid tumor or CNS malignancy.

Performance status: Patients over 16 years of age must have a Karnofsky score greater than or equal to 50. Children under 16 years of age must have a Lansky score greater than or equal to 50.

Prior therapy: Patients may have received prior therapy with vincristine, irinotecan, or temozolomide. They may not however have received therapy that included a treatment cassette of irinotecan and temozolomide in combination.

Prior myelosuppressive therapy: Patients must have not received myelosuppressive therapy in 3 weeks or nitrosourea chemotherapy within 6 weeks of initiation of protocol therapy.

Hematologic growth factor support: Patients may not have received G-CSF within the previous 3 days or peg-filgrastim within the past 7 days.

Biologic anti-neoplastic therapy: At least 21 days or 5 half-lives (whichever is of longer duration) must have elapsed since the last administration of biologic antineoplastic therapy.

Radiation therapy: ≥ 14 days since the last dose of local XRT; ≥ 6 months must have elapsed if prior TBI, craniospinal XRT or ≥ 50% radiation of pelvis; ≥ 6 wks must have elapsed if other substantial BM radiation.

Autologous or allogeneic stem cell transplant: No active graft vs. host disease or need for immunosuppressive therapy. At least 3 months must have passed since neutrophil engraftment.

Organ function: Bone marrow function:

Peripheral absolute neutrophil count (ANC) greater than or equal to 1000 cells/mcL.

Platelet count greater than or equal to100,000/mcL and no platelet transfusion within prior 7 days.

Hemoglobin greater than or equal to 8 gm/dL

Patients with known bone marrow metastatic disease may enroll on the study if they have a peripheral ANC greater than or equal to 750 cells/mcL. They will not be evaluable for hematologic toxicity. \- Adequate liver function:

Total bilirubin less than or equal to 1.5x upper limit of normal (ULN) for age.

SGPT (ALT) less than or equal to 5x ULN

Serum albumin greater than or equal to 2 gm/dL \- Adequate renal function:

Creatinine clearance or glomerular filtration rate \>70 ml/min/1.73 m2 or a serum creatinine based on age and gender as follows: Age Maximum serum creatinine concentration (mg/dL) Male Female 1-\<2 years 0.6 0.6 2-\<6 years 0.8 0.8 6-\<10 years 1 1 10-\<13 years 1.2 1.2 13-\<16 years 1.5 1.4 greater than or equal to 16 years 1.7 1.4 The threshold creatinine values in this table were derived from the Schwartz formula to estimate glomerular filtration rates (Schwartz et al. J. Peds. 106; 522. 1985) using child length and stature data from the CDC. \- Informed consent: All patients less than 18 years of age must sign a written informed consent. For patients \<18 years of age, a parent or guardian must sign a written informed consent, unless the patient is an emancipated minor. Childhood assent, when appropriate, should be obtained as well per institutional guidelines.

Exclusion Criteria

Pregnancy or breast feeding: Women who are pregnant or breast feeding will not be entered on the protocol due to the risks of fetal and teratogenic adverse events with the therapeutic agents used in the protocol therapy.

Corticosteroid use: Patients with CNS tumors who have not been on a stable or decreasing dose of corticosteroids for the 7 days prior to the initiation of protocol therapy.

Antineoplastic therapy: Patients receiving any other antineoplastic therapy.

Medication allergy: Allergy or intolerance to any of the protocol agents: vincristine, irinotecan, temozolomide, or vorinostat. Allergy or intolerance to cephalosporins.

Infection: Patients who have any uncontrolled infection, positive blood culture within 48 hours prior to protocol entry, or diagnosed or receiving therapy for Clostridium difficile infection.

Patients may not have taken valproic acid or any other histone deacetylase inhibitor for at least 2 weeks prior to study enrollment.

Children with neurofibromastosis Type 1, if being used for treatment of a low grade glioma.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Valhalla?

Yes, this clinical trial (NCT04308330) has an active research site in Valhalla, NY that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Ewing Sarcoma Treatment Options in Valhalla, NY

If you're searching for ewing sarcoma treatment options in Valhalla, NY, this clinical trial (NCT04308330) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Valhalla research site is actively enrolling participants for this phase 1 clinical trial. You'll receive care from experienced ewing sarcoma specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all ewing sarcoma clinical trials near you to find additional studies recruiting in your area.

Ewing Sarcoma Clinical Trial in Valhalla, NY

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