NCT05673915 · Mayo Clinic
Study of Transcranial Direct Current Stimulation to Treat Epilepsy
What this study is about
The purpose of this research is to see to what extent electrical stimulation applied to the scalp (transcranial direct current stimulation or tDCS) can reduce the number and intensity of epileptic seizures.
View original scientific description
The purpose of this research is to see to what extent electrical stimulation applied to the scalp (transcranial direct current stimulation or tDCS) can reduce the number and intensity of epileptic seizures.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Clinical diagnosis of generalized onset or focal epilepsy or sleep-related epileptic encephalopathy.
- Estimated to have at least 2 countable seizures per month or spike-wave index ≥50%.
- Has not had control with at least 2 anti-seizure medicines.
- Able to maintain a constant medication for duration of the study (rescue meds allowed).
- Subject or legally authorized representative is able to understand consent and keep a seizure diary in English.
Exclusion criteria
- A disease likely to progress over course of the study.
- Psychogenic non-epileptic seizures.
- Suicide attempt or psychiatric hospitalization past 2 years.
- A skin condition interfering with scalp electrodes or allergy to silver.
- Women will verify not pregnant, and if applicable, have a serum pregnancy test.
- Implanted devices (e.g. pacemakers)-except VNS, which is allowed.
Where
- Rochester, Minnesota
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jan 28, 2026 · Source of record for eligibility and locations