NCT06960421 · University of California, San Francisco
Exercise-based Frailty Intervention in Lung Transplantation (XFIT)
(XFIT)
What this study is about
The goal of XFIT study is to measure the safety of an 8-week telehealth-delivered exercise and behavioral training program to treat frailty in lung transplant candidates in their own home.
View original scientific description
The goal of XFIT study is to measure the safety of an 8-week telehealth-delivered exercise and behavioral training program to treat frailty in lung transplant candidates in their own home. The main questions XFIT aims to answer are: * Is XFIT safe? * Is XFIT feasible and acceptable by participants? * Is XFIT effective in improving frailty and physical function as reflected in patient-reported outcomes.
Interventions
BEHAVIORAL
XFIT
XFIT is an 8-week telehealth-delivered, home-based exercise/behavior modification intervention. It integrates theoretical frameworks of behavior change to engage frail lung transplant candidates in program of pre-habilitation.
Primary outcome measures
Death
Time frame: 8 weeks
Major cardiovascular event
Time frame: 8 weeks
> 2 unplanned hospitalizations
Time frame: 8 weeks
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Age 18 - 65 years
- Lung Transplant Candidates
- Speaks English or Spanish
- ≤ 8LPM O2 on 6MWT
- SPPB score ≤ 10
Exclusion criteria
- Lives Alone
- BMI \< 18.0 kg/m2
- Engaged in clinical pulmonary rehabilitation program
- Severe pHTN (RHC mPAP ≥ 30 mmHg or TTE PASP ≥ 60mmHg or moderately/severely reduced RV systolic function on TTE
- Deemed unsafe by site PI Group 2 Inclusion Criteria:
- Age 18 - 75 years
- Speaks English or Spanish
- ≤ 15LPM O2 on 6MWT
- SPPB score ≤ 10 Exclusion Criteria:
- Lives Alone
- BMI \< 18.0 kg/m2
- Engaged in clinical pulmonary rehabilitation program
- Severely reduced RV systolic function on TTE
- Deemed unsafe by site PI
Where
- San Francisco, California
- New York, New York
- Chapel Hill, North Carolina
- Philadelphia, Pennsylvania
Collaborators
University of Pennsylvania, University of North Carolina, Columbia University, National Heart, Lung, and Blood Institute (NHLBI)
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Oct 16, 2026 · Source of record for eligibility and locations