Louisville, KYNCT04661215Now EnrollingIRB Ready

Gastroparesis Clinical Trial in Louisville, KY

Access cutting-edge gastroparesis treatment through this clinical trial at a research site in Louisville. Study-provided care at no cost to qualified participants.

Sponsored by Johns Hopkins Bloomberg School of Public Health

Quick Self-Assessment

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Expert Care in Louisville

Access gastroparesis specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related gastroparesis treatment provided free

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Check if you qualify for this gastroparesis clinical trial in Louisville, KY

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Louisville

    Convenient for KY residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Louisville site if eligible
  4. 4Begin participation

About This Gastroparesis Study in Louisville

The overall objective of this study is to determine if there are pyloric sphincter abnormalities in patients with gastroparesis symptoms and determine how prevalent these abnormalities are using tests to assess the pyloric sphincter - endoluminal functional luminal imaging probe (Endoflip™), water load satiety testing (WLST), and high-resolution cutaneous electrogastrography (HR-EGG) using Gastric Alimetry™ System.

Sponsor: Johns Hopkins Bloomberg School of Public Health

Who Can Participate

Inclusion Criteria

FOR SYMPTOMATIC PARTICIPANTS:
Provision of signed and dated informed consent form.
Stated willingness to comply with all study procedures and availability for the duration of the study.
Male or female, aged 18-85
Symptoms of gastroparesis, either diabetic or idiopathic etiology
Symptoms of gastroparesis with minimum Gastroparesis Cardinal Symptom Index (GCSI) score of 2.0
Individual will have had a prior 4-hour gastric emptying scintigraphy test performed for clinical evaluation within the last 6 months. This gastric emptying test would be done for clinical evaluation and is not part of the research study. From these participants with gastroparesis symptoms, we will include those with delayed gastric emptying as well as those with normal gastric emptying.
Participant must not initiate any new treatments until completion of the study procedures.
Willingness to:
Stop histamine 2 antagonists, prokinetics (e.g., metoclopramide, erythromycin, domperidone, prucalopride), narcotics, anticholinergics, constipation medications (over the counter laxatives, isotonic polyethylene glycol (PEG) electrolyte preparations (e.g. MiraLax), prescription laxatives (e.g. lubiprostone), proton pump inhibitors, cannabinoids, and cannabidiol (CBD) for 3 days prior to each visit;
Abstain from food and water after midnight (at least for 8 hours) before the start of each visit until after the visit. INCLUSION CRITERIA FOR CONTROL PARTICIPANTS
Provision of signed and dated informed consent form
Male or female, aged 18 or older
Undergoing an upper endoscopy for their clinical evaluation of diarrhea, GI bleed, or iron-deficiency anemia, or evaluation for bariatric surgery.
Do not have upper GI symptoms greater than 1 as assessed by the Gastroparesis Cardinal Symptom Index (GCSI) of PAGI-SYM questionnaire.

Exclusion Criteria

Prior gut lumen surgery on the esophagus or the stomach, including Nissen fundoplication.
Prior surgery on the pylorus (G-POEM, surgical pyloroplasty, surgical pyloromyotomy)
Known history of achalasia or esophageal stricture
Known history of physiological or mechanical GI obstruction
Abnormalities seen on a prior upper endoscopy placing patient at increased risk:
Ulcer of the esophagus, stomach, or duodenum
Esophageal varices
Individuals at risk for prolonging the endoscopy procedure: severe chronic pulmonary disease, severe food retention in the stomach on endoscopy.
Presence of significant gastric or duodenal pathology that could be expected to cause dysmotility (e.g. significant inflammation, infiltrate disorders etc)
Individuals with a history of other chronic disease potentially causative of gastrointestinal symptom
Acute or chronic renal insufficiency
Current eating disorders
Females who are pregnant. A urine pregnancy test is routinely obtained on all females immediately prior to endoscopic procedures.
Individuals with contraindications for endoscopy, including bleeding abnormalities
Allergy to eggs preventing sedation with propofol and/or gastric emptying test
Significant dysphagia
Prior inflammatory bowel disease, Crohn's
History of any esophageal/gastric/pyloric injection of botulinum toxin
Patients on daily opioid use or \>3 day/week use
Use of glucagon-like peptide 1 (GLP1) receptor agonists or Sodium-Glucose Transport Protein 2 (SGLT2); Gastric inhibitory polypeptide (GIP)- glucagon-like peptide (GLP) combo

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Louisville?

Yes, this clinical trial (NCT04661215) has an active research site in Louisville, KY that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Gastroparesis Treatment Options in Louisville, KY

If you're searching for gastroparesis treatment options in Louisville, KY, this clinical trial (NCT04661215) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Louisville research site is actively enrolling participants for this clinical trial. You'll receive care from experienced gastroparesis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all gastroparesis clinical trials near you to find additional studies recruiting in your area.

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