Is NCT06064695 recruiting in Fairway, KS?

Yes, NCT06064695 is currently recruiting participants at its Fairway, KS location. This generalized myasthenia gravis clinical trial is actively enrolling qualified participants.

How do I join the generalized myasthenia gravis clinical trial in Fairway?

To join this clinical trial in Fairway, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Fairway clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Generalized Myasthenia Gravis Clinical Trial in Fairway, KS

About This Generalized Myasthenia Gravis Study in Fairway

During this pilot study, the investigators will examine the effects of whole-body electrical muscle stimulation exercise (WB-EMS Exercise) on neuromuscular junction (NMJ) transmission and fatigability in adults with Generalized Myasthenia Gravis (gMG). The investigators will also test whether a relationship exists between NMJ transmission dysfunction and fatigability in gMG, which has long been presumed but never directly assessed. Participants will undergo clinical and electrophysiologic testing before and after the WB-EMS Exercise intervention. The WB-EMS Exercise intervention will be delivered 2 times per week for 4 weeks. Long-term follow up is optional. The hypotheses are (a) that the WB-EMS exercise will improve fatigability and NMJ transmission, and (b) that NMJ transmission dysfunction is related to fatigability.

Sponsor: University of Missouri-Columbia

Who Can Participate

Inclusion Criteria

for Participants with MG:

Age 18 or older

Diagnosed with Generalized Myasthenia Gravis (gMG) via seropositive test for acetylcholine receptor (AChR) antibodies or seronegative test with clinical symptoms consistent with gMG

On stable MG therapy for at least 1 month

Ability to stand for approximately 15 minutes continuously with or without an assistive device (i.e. the length of time to stand to take a shower, complete meal preparation, wait in line at the bank, etc.)

Score of 1 (Mild) or 2 (Moderate) on at least one side of the "arm outstretched" and "leg outstretched" items of the QMG, demonstrating fatigability

At least some anti-gravity strength in major muscle groups as assessed by manual muscle testing (i.e. 2+/5 strength or better)

Medical clearance to participate in an exercise program

Ability to provide informed consent

Ability to conform to the requirements of the study (i.e. attendance at assessment and intervention visits, maintain current level of non-study physical activity for the duration of the study, no intention to relocate mid-study)

Exclusion Criteria

for Participants with MG:

Concurrent participation in another interventional research study

Unable to tolerate 15 minutes of continuous standing with or without an assistive device

Regular participation in strength training (2x per week or more over the past 6 months)

Score of 0 (None) on all "arm outstretched" and "leg outstretched" items of the QMG

Presence of a pacemaker, metal implants, or other implanted medical devices that could impact participant safety during WB-EMS intervention

Presence of unstable acute or chronic disease (i.e. renal failure, rheumatologic disease, cardia arrhythmia, neoplasm, uncontrolled hypertension)

Known pregnancy at time of screening

Presence of a terminal disease (i.e. receiving hospice services)

Current or previous use of any drugs known to influence muscle mass or performance within 6 months; these may include but are not limited to anabolic steroids, IGF01, growth hormone, replacement androgen therapy, anti-androgen therapy

Presence of an additional neuromuscular or neurologic condition affecting somatosensory or motor function/control (i.e. motor neuron disease, muscle disease, peripheral neuropathy, other NMJ condition, Parkinson's disease, Multiple Sclerosis, h/o stroke, traumatic brain injury, spinal cord injury, ataxia, apraxia, hemiplegia, etc.)

Musculoskeletal condition or surgery in the past year that would confound results of exercise interventions (i.e. knee replacement, hip replacement, rotator cuff repair, spinal fusion)

Other medical conditions, signs, or symptoms that would interfere with study conduct or interpretation of results as determined by an investigator Inclusion Criteria for Healthy Controls:

Age 18-39 years

Ability to provide informed consent Exclusion Criteria for Healthy Controls:

Concurrent participation in an interventional research study

Presence of unstable acute or chronic disease (i.e. renal failure, rheumatologic disease, cardia arrhythmia, neoplasm, uncontrolled hypertension)

Presence of a terminal disease (i.e. receiving hospice services)

Musculoskeletal condition or surgery in the past year that would confound results of exercise interventions (i.e. TKA, THA, RTC repair, spinal fusion)

Other medical conditions, signs, or symptoms that would interfere with study conduct or interpretation of results as determined by an investigator Healthy controls will complete dEMG testing only during a one-time session.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Fairway?

Yes, this clinical trial (NCT06064695) has an active research site in Fairway, KS that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Generalized Myasthenia Gravis Treatment Options in Fairway, KS

If you're searching for generalized myasthenia gravis treatment options in Fairway, KS, this clinical trial (NCT06064695) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Fairway research site is actively enrolling participants for this clinical trial. You'll receive care from experienced generalized myasthenia gravis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all generalized myasthenia gravis clinical trials near you to find additional studies recruiting in your area.

Generalized Myasthenia Gravis Clinical Trial in Fairway, KS

Expert Care in Fairway

IRB Approved

No-Cost Care

Apply for This Fairway Location

Why Participate?

Simple Process