Is NCT05992311 recruiting in Houston, TX?

Yes, NCT05992311 is currently recruiting participants at its Houston, TX location. This gulf war syndrome clinical trial is actively enrolling qualified participants.

How do I join the gulf war syndrome clinical trial in Houston?

To join this clinical trial in Houston, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Houston clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Gulf War Syndrome Clinical Trial in Houston, TX

About This Gulf War Syndrome Study in Houston

The study addresses the pre-clinical promise of Montelukast (MLK) for improving brain function in veterans with Gulf War Illness (GWI). MLK, a US Food and Drug administration (FDA)-approved drug for asthma, has shown efficacy in an animal model of GWI to improve cognitive and mood function through modulation of leukotriene signaling and suppression of neuroinflammation.

Sponsor: Baylor College of Medicine

Who Can Participate

Inclusion Criteria

Gulf War Veterans of the U.S. military deployed on military orders to the Persian Gulf Region between August 2, 1990, and December 31, 1991

Diagnosed with GWI according to the CDC and modified Kansas criteria as recommended by the Institute of Medicine (IOM), that is, endorse multiple or moderate-to-severe symptoms, with symptom onset during or after deployment to the Persian Gulf region in 1990-1991, persisting for six months or longer, in at least 3 of 6 domains:

fatigue/sleep disturbances

neurological/cognitive/mood symptoms

somatic pain

gastrointestinal problems

respiratory symptoms

skin symptoms

Self-reported cognitive dysfunction based on a T-score of 40 or less on the PROMIS v2.0 Cognitive Function 8a short form

Be able to:

provide written consent and be able to communicate with the research team in verbal and written English

attend the two in-person study encounters

have reliable telephone service for the eight weekly telephone encounters

Exclusion Criteria

Diagnosed by a physician with any chronic condition that may explain their profile of symptoms or prevent their ability to accurately report them including:

chronic autoimmune conditions

systemic inflammatory conditions

cancer not in remission at least 5 years

congestive heart failure

multiple sclerosis

amyotrophic lateral sclerosis (ALS)

poorly controlled diabetes

post-chemo or radiation syndromes

sickle cell anemia

symptomatic Coronary Artery Disease (CAD)

chronic liver disease

chemical insufficiency

morbid obesity (body mass index (BMI) \>= 40)

human immunodeficiency virus (HIV)

alcohol/substance use disorder/stimulant/opioid/other depressant misuse in the past year

major mental health condition (e.g., psychosis, suicidal ideations, major depressive disorder) that interferes with their ability to accurately report symptoms

hospitalized or undergoing invasive procedures in the past 12 months due to exacerbations of any chronic conditions (such as diabetes, coronary artery disease, hypertension, or emphysema)

elevated liver enzymes (2.5 times upper limit of normal) at baseline visit

estimated glomerular filtration rate less than 60 ml/min/1.73 sqm at baseline visit

hemoglobin less than 10 g/L at baseline visit

evidence of poorly controlled chronic conditions listed above, or others that may mimic GWI as per the PI, either by self-report, Veterans Health Administration (VHA) electronic health record information review, laboratory testing or physical examination

Changes in medications for chronic conditions in the 3 months preceding enrollment (based on self-report)

Suicidal ideation based on their responses on the Columbia Suicide Risk Inventory

Prescribed or taking Montelukast in the past 6 months for any reason

Taking 2 or more medications with moderate interactions with Montelukast

Pregnancy or intention to become pregnant

Active homicidal ideation

COVID-19 illness (confirmed or suspected) without recovery to pre-COVID health status

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Houston?

Yes, this clinical trial (NCT05992311) has an active research site in Houston, TX that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Gulf War Syndrome Treatment Options in Houston, TX

If you're searching for gulf war syndrome treatment options in Houston, TX, this clinical trial (NCT05992311) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Houston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced gulf war syndrome specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all gulf war syndrome clinical trials near you to find additional studies recruiting in your area.

Gulf War Syndrome Clinical Trial in Houston, TX

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