NCT07514013 · Applied Food Sciences Inc.
Examining Olive Oil Extract on Knee Comfort and Function
What this study is about
The goal of this study is to learn if an olive oil extract works to improve knee pain and discomfort in adults.
View original scientific description
The goal of this study is to learn if an olive oil extract works to improve knee pain and discomfort in adults. The main questions it aims to answer are: 1) Does the olive oil extract improve the perceptions of knee pain and discomfort, and 2) Does the olive oil extract improve knee function in adults? The main procedures in the study include: * Screening and informed consent * Take one assigned study capsule (supplement or placebo) daily with food for 6 weeks * Complete digital questionnaires about your knee pain, stiffness, and function at scheduled times * Complete a Day 1 acute assessment and two simple functional movement tests at home as described below * If possible, connect a compatible wearable device to allow collection of sleep and physical activity data as detailed below.
Interventions
DIETARY_SUPPLEMENT
Olive Oil Extract
The investigational product is an olive oil extract dietary supplement formulated for oral consumption. The product is provided in capsule form and is intended for general wellness use, including support of joint comfort and function. Each capsule delivers a standardized amount of olive-derived bioactive compounds, including oleocanthal and oleacein.
DIETARY_SUPPLEMENT
Placebo
The comparator product is a matched placebo formulated from refined olive oil extract and is similar in appearance, taste, and packaging to the investigational product. The placebo is intended to serve as a control for study comparisons and does not contain the standardized olive-derived bioactive compounds present in the investigational product.
Primary outcome measures
Change in Knee pain (KOOS Pain subscale)
Time frame: After 0, 1, 2, 3, 4, 5, and 6 weeks of supplementation.
Change in knee pain from baseline to Week 6. Measured by KOOS (0-100 where 0=Worst knee problems, 100=No knee problems).
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Participants must meet all of the following criteria to be eligible for participation:
- Adults aged 40 to 75 years
- Self-reported knee discomfort for at least 3 months
- Willing and able to take one study capsule daily for the duration of the study
- Willing and able to complete digital questionnaires, functional movement tasks, and other study activities using the Alethios platform
- Willing and able to wear a compatible activity-tracking device throughout the study
- Willing and able to collect saliva samples at home using a provided kit, if applicable
- Able to read and understand English
- Willing to provide informed consent electronically
Exclusion criteria
- Participants will be excluded if any of the following apply:
- Diagnosis of inflammatory joint disease (e.g., rheumatoid arthritis) or other systemic inflammatory conditions affecting the knee
- Any current or prior diagnosis from a licensed medical provider of knee disease
- Knee surgery or significant knee injury within the past 6 months
- Planned knee surgery during the study period
- Known allergy or sensitivity to olive-derived products or any component of the study product
- Current use of investigational drugs or participation in another research study during the study period
- Any medical condition or circumstance that, in the opinion of the investigator, would make participation unsafe or interfere with study participation or data quality
Where
- San Francisco, California
Collaborators
Alethios, Inc.
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Apr 15, 2026 · Source of record for eligibility and locations