Iowa City, IANCT06633913Now EnrollingIRB Ready

Healthy Control Clinical Trial in Iowa City, IA

Access cutting-edge healthy control treatment through this clinical trial at a research site in Iowa City. Study-provided care at no cost to qualified participants.

Sponsored by Jing Jiang

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Expert Care in Iowa City

Access healthy control specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related healthy control treatment provided free

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Check if you qualify for this healthy control clinical trial in Iowa City, IA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Iowa City

    Convenient for IA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Iowa City site if eligible
  4. 4Begin participation

About This Healthy Control Study in Iowa City

The goal of this clinical trial is to examine the neural mechanisms underlying transcranial magnetic stimulation (TMS) using concurrent functional magnetic resonance imaging (fMRI) in both healthy controls (HCs) and patients with high negative affect symptoms, such as depression. Approximately half male and half female participants aged 18-65 will be recruited. The main questions it aims to answer are: 1. Is the acute/transient effect induced by single-pulse TMS related to the long-term modulatory effect induced by repetitive TMS (rTMS)? 2. Do any of these effects predict negative affect symptoms, such as depression? Participants will: 1. Complete several tests to assess their cognitive abilities and emotional states 2. Undergo several brain scans, including resting-state fMRI, structural MRI, diffusion tensor imaging (DTI), and task fMRI 3. Have two different types of TMS sequences, single-pulse and repetitive pulses, administered to specific brain regions while undergoing fMRI

Sponsor: Jing Jiang

Who Can Participate

Inclusion Criteria

for patients:
Diagnosis of major depressive disorder
Age greater than or equal to 18 years
Age less than or equal to 65 years
Able to understand and consent for research participation
English-speaking Inclusion for healthy controls:
Report no lifetime psychiatric diagnosis and treatment
scores on Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder Questionnaire (GAD-7) lower than 4
Age greater than or equal to 18 years
Age less than or equal to 65 years
Able to understand and consent for research participation
English-speaking

Exclusion Criteria

for all subjects:
Age less than 18 years
Age greater than 65 years
With epilepsy or seizure disorder
With implanted ferromagnetic equipment in their face or skull near the stimulation target MRI Exclusion criteria for all subjects:
Implanted device including pacemaker, coronary stent, defibrillator, or neurostimulation device that is not MRI-compatible
Metal in body including bullets, shrapnel, metal slivers
Claustrophobia
Uncontrolled high blood pressure
Blood circulation problems
Opiate medication, antihypertensive medication, or any medication that interferes with blood flow (interferes with fMRI recordings)
Significant heart disease, such as atrial fibrillation
Pregnancy in female participants
Prior exposure to deep brain stimulation, rTMS, or tDCS (transcranial direct current stimulation) therapies
History of neurological or cardiovascular disorders, brain surgery, radiation treatment, brain hemorrhage or tumor, stroke, or diabetes
Significant traumatic brain injury (loss of consciousness, post-injury amnesia, significant radiological/neurological findings, penetrating brain injury)
Refusal to abstain from illicit drug use for duration of the study
Refusal to abstain from alcohol within 24 hours of scans If you would like to participate in the study, click this link to fill out the Screening Form: https://redcap.icts.uiowa.edu/redcap/surveys/?s=DEYHWF8TMCHHW4Y7. Kindly note that our research team will contact you directly only if you meet the eligibility criteria for the study. Due to the high volume of responses, we are unable to reply to individual inquiries or provide feedback about eligibility decisions.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Iowa City?

Yes, this clinical trial (NCT06633913) has an active research site in Iowa City, IA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Healthy Control Treatment Options in Iowa City, IA

If you're searching for healthy control treatment options in Iowa City, IA, this clinical trial (NCT06633913) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Iowa City research site is actively enrolling participants for this clinical trial. You'll receive care from experienced healthy control specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

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