Is NCT06980428 recruiting in Brooklyn, MD?

Yes, NCT06980428 is currently recruiting participants at its Brooklyn, MD location. This healthy participants clinical trial is actively enrolling qualified participants.

How do I join the healthy participants clinical trial in Brooklyn?

To join this clinical trial in Brooklyn, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Brooklyn clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Healthy Participants Clinical Trial in Brooklyn, MD

About This Healthy Participants Study in Brooklyn

The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple ascending doses of AZD4954 in healthy participants with or without elevated Lipoprotein(a) (Lp\[a\]) levels and participants with dyslipidemia.

Sponsor: AstraZeneca

Who Can Participate

Inclusion Criteria

Participants with plasminogen level (concentration) within normal range at the Screening Visit.

All females must have a negative pregnancy test at the Screening Visit and on admission to the study site.

Females of childbearing potential must not be lactating and if heterosexually active must agree to use an approved method of highly effective contraception.

Females of non-childbearing potential must be confirmed at the Screening Visit.

Sexually active fertile male participants with partners of childbearing potential must adhere to the study specific contraception methods from the time of first administration of study intervention until 3 months after the study Follow-up Visit. Parts A and B (Healthy Participants):

Male and female participants aged 18 to 65 years with suitable veins for cannulation or repeated venipuncture.

Have a body mass index (BMI) between 18 and 35 kg/m² inclusive.

For Japanese and Chinese participants (Parts A and B):

A Japanese participant is defined as having both parents and 4 grandparents who are ethnically Japanese. This includes second and third generation Japanese whose parents or grandparents are living in a country other than Japan.

A Chinese participant is defined as having both parents and 4 grandparents who are ethnically Chinese. This includes second and third generation Chinese whose parents or grandparents are living in a country other than China. Part B (Healthy Participants):

Participants must have elevated Lp(a) ≥ 30 mg/dL at the Screening Visit. Part B (Participants with Dyslipidemia):

Male and female participants aged 18 to 70 years with suitable veins for cannulation or repeated venipuncture.

Have a BMI \> 18 kg/m².

Participants must have elevated Lp(a) ≥ 70 mg/dL at the Screening Visit.

Participants with a fasting LDL-C ≥ 70 mg/dL and \< 190 mg/L at the Screening Visit.

Participants should be receiving moderate or high-intensity statin therapy for ≥ 2 months prior to the Screening Visit, according to the American College of Cardiology/American Heart Association guidelines on blood cholesterol management.

Participants with documented coronary artery disease, stroke, or peripheral artery disease or at moderate or high risk for an atherosclerotic cardiovascular disease event.

There should be no planned medication or dose change during study participation.

Exclusion Criteria

History of any clinically important disease or disorder.

History or presence of gastrointestinal, hepatic, or renal disease or any other condition known to interfere with absorption, distribution, metabolism, or excretion of drugs.

Any clinically important illness, medical/surgical procedure, or trauma within 4 weeks of the first administration of study intervention.

Participants with known bleeding or coagulation disorders.

Participants who have an elevated high-sensitivity C-reactive protein (\> 3 mg/L) or have a prothrombin time/international normalized ratio (PT/INR) or activated partial thromboplastin time (aPTT) \> 1.25 times × upper limit normal (ULN).

Any clinically important abnormalities in hematology, coagulation, clinical chemistry, urinalysis, abnormal vital signs or abnormal laboratory values.

Any positive result on Screening for serum hepatitis B surface antigen (HBsAg), hepatitis B core antibody (HBcAb), hepatitis C virus (HCV) or human immunodeficiency virus (HIV).

Any clinically important abnormalities in rhythm, conduction, or morphology of the resting 12-lead electrocardiogram (ECG) at Screening.

Use of drugs with enzyme inducing properties such as St John's Wort within 3 weeks prior to the first administration of study intervention. Parts A and B (Healthy Participants):

Use of any prescribed or nonprescribed medication including antacids, analgesics (other than paracetamol/acetaminophen), herbal remedies, intake of \> 3 × daily recommended levels of vitamins and minerals during the 2 weeks prior to the first administration of study intervention or longer if the medication has a long half-life.

Current smokers or those who have smoked or used nicotine products. Part B (Participants with Dyslipidemia):

Acute ischemic cardiovascular event in the last 12 months prior to randomization.

Poorly controlled diabetes.

Previous administration of Lp(a) inhibitor.

Have uncontrolled hypertension.

Abnormal vital heart rate.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Brooklyn?

Yes, this clinical trial (NCT06980428) has an active research site in Brooklyn, MD that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Healthy Participants Treatment Options in Brooklyn, MD

If you're searching for healthy participants treatment options in Brooklyn, MD, this clinical trial (NCT06980428) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Brooklyn research site is actively enrolling participants for this clinical trial. You'll receive care from experienced healthy participants specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all healthy participants clinical trials near you to find additional studies recruiting in your area.

Healthy Participants Clinical Trial in Brooklyn, MD

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