St Louis, MONCT06895070Now EnrollingIRB Ready

Heart Transplant Clinical Trial in St Louis, MO

Access cutting-edge heart transplant treatment through this clinical trial at a research site in St Louis. Study-provided care at no cost to qualified participants.

Sponsored by XVIVO Perfusion

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Expert Care in St Louis

Access heart transplant specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related heart transplant treatment provided free

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Check if you qualify for this heart transplant clinical trial in St Louis, MO

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Why Participate?

  • No-Cost Study Care

  • Local to St Louis

    Convenient for MO residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit St Louis site if eligible
  4. 4Begin participation

About This Heart Transplant Study in St Louis

The purpose of this study is to evaluate if Non-Ischemic Heart Preservation (NIHP) of extended criteria donor hearts using the XVIVO Heart Preservation System (XHPS) is a safe and effective way to preserve and transport hearts for transplantation.

Sponsor: XVIVO Perfusion

Who Can Participate

Inclusion Criteria

Recipient: To be eligible to participate in this study, a recipient must meet all the following criteria:
Age ³18 years.
Signed informed consent form (ICF).
Listed for heart transplantation.

Exclusion Criteria

Previous solid organ or bone marrow transplantation.
Requires a multi-organ transplant.
Subject is enrolled and ongoing in another investigational pharmaceutical or medical device clinical trial (Exception: observational studies are permitted).
Subject is on mechanical circulatory support pre-transplant other than durable LVAD, Impella or intra-aortic balloon pump (IABP).
History of complex congenital heart disease ie: single ventricle physiology (per Investigator's discretion and XVIVO review).
Subject on renal replacement therapy/dialysis.
Ventilator dependence (subject is intubated at time of transplant/unable to provide consent or re-affirmation of consent).
Sensitized participants meeting any of the following:
Participant with calculated Panel Reactive Antibody (cPRA) greater than 50%
Participant undergoing any desensitization treatment (also with cPRA less than 50%)
Participant with a positive prospective crossmatch and/or a positive virtual cross match Donor Inclusion Criteria: To be eligible to participate in this study, the donor heart must meet the following criteria:
Estimated Cross Clamp Time ≥4 hours OR
Estimated Cross Clamp ≥ 2 hours AND Any one or more of the following:
Age ≥50 years
LVEF 40% - 50% at time of provisional acceptance. (Refer to section 6.3.4 for definition of provisional acceptance).
Down-time ≥20 minutes
Hypertrophy septal thickness \>12 - ≤16mm
Angiographic luminal irregularities with no significant CAD OR 1) Donation after Circulatory Death (DCD) Donor Exclusion Criteria: Donor hearts that meet any of the following criteria will be excluded from transplantation in this study:
Unstable hemodynamics requiring high-dose inotropic support.
Significantly abnormal coronary angiogram defined as CAD \> 50% stenosis of one or more vessels or if the donor heart exhibits any contusions, structural damage, gross abnormalities, or palpable CAD on final examination.
Moderate to severe cardiac valve pathology.
Investigator's clinical decision to exclude from trial.
Previous sternotomy.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in St Louis?

Yes, this clinical trial (NCT06895070) has an active research site in St Louis, MO that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Heart Transplant Treatment Options in St Louis, MO

If you're searching for heart transplant treatment options in St Louis, MO, this clinical trial (NCT06895070) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our St Louis research site is actively enrolling participants for this clinical trial. You'll receive care from experienced heart transplant specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all heart transplant clinical trials near you to find additional studies recruiting in your area.

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