Is NCT07401862 recruiting in Orlando, FL?

Yes, NCT07401862 is currently enrolling participants at its Orlando, FL location. This hepatic insufficiency clinical trial is accepting qualified participants.

How do I join the hepatic insufficiency clinical trial in Orlando?

To join this clinical trial in Orlando, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Orlando clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Hepatic Insufficiency Clinical Trial in Orlando, FL: LY3841136 (Phase 1)

About This Hepatic Insufficiency Study in Orlando

The main purpose of this study is to evaluate how a medicine, LY3841136, works in participants with different levels of liver damage and in participants with healthy liver. The researchers want to see how the medicine is absorbed and used by the body, and if it causes any side effects, in participants with mild, moderate, or severe liver damage, as well as in participants with normal liver function. For each participant, the study will last about 14 weeks, which will include a stay at the clinical research unit for 5 nights.

Sponsor: Eli Lilly and Company

Who Can Participate

Inclusion Criteria

Have a body weight of 55 kilograms (kg) or more and body mass index between 19.0 and 40.0 kilograms per square meter (kg/m²), inclusive Group 1

Are healthy as determined by medical history, physical examination, and other screening procedures, with clinically normal hepatic function at screening Groups 2 through 4

Have hepatic impairment classified as Child-Pugh score A, B, or C (mild, moderate, or severe impairment who are considered acceptable for participation in this study by the investigator. Participants must have a diagnosis of chronic hepatic impairment of greater than 6 months per physician diagnosis and standard-of-care practice, with no clinically significant changes in the opinion of the investigator within 15 days prior to screening Participants with hepatic impairment may have stable baseline medical conditions for which neither the condition nor treatments received would negatively impact the health of the participant or study conduct

Exclusion Criteria

Have a history or presence of chronic or acute pancreatitis or elevation in serum amylase or lipase greater than 1.5 × upper limit of normal (ULN)

Are pregnant or intend to become pregnant or to breastfeed during the study Group 1

Have liver disease, obvious clinical signs or symptoms of liver disease, acute or chronic hepatitis, or have elevations in aspartate aminotransferase (AST) or alanine transaminase (ALT) greater than 1.5 × ULN or total bilirubin (TBL) greater than 1.5 × ULN at screening

Have a current infection with hepatitis B virus (HBV), that is,

if hepatitis B surface antigen (HBsAg) is positive, the participant is excluded, or

if HBsAg is negative and anti-Hepatitis B core antibody (HBc) is positive, further testing for HBV deoxyribonucleic acid (DNA) is required, and

if the screening HBV DNA is positive, the participant is excluded

Have a current infection with hepatitis C virus (HCV), that is,

if anti-HCV is positive, a test for circulating HCV ribonucleic acid (RNA) is required, and

if HCV RNA test is positive, the participant is excluded Groups 2, 3, and 4

Have presence of active portal shunt or transjugular intrahepatic portosystemic shunt

Require paracentesis more often than 2 times per month or are expected to require paracentesis during the study

Have evidence of spontaneous bacterial peritonitis within 6 months of screening

Have had variceal bleeding within 3 months of screening. If the participant has undergone a successful banding procedure, they may participate in the study providing at least 1 month has passed after the banding procedure at the time of screening

Show presence of hepatocellular carcinoma

Have hepatic encephalopathy of Grade 2 or higher

Have TBL greater than 15 milligrams per deciliter (mg/dL)

Have ALT greater than or equal to 6 × ULN

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Orlando?

Yes, this clinical trial (NCT07401862) has an active research site in Orlando, FL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Hepatic Insufficiency Treatment Options in Orlando, FL

If you're searching for hepatic insufficiency treatment options in Orlando, FL, this clinical trial (NCT07401862) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Orlando research site is actively enrolling participants for this phase 1 clinical trial. You'll receive care from experienced hepatic insufficiency specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all hepatic insufficiency clinical trials near you to find additional studies recruiting in your area.

Hepatic Insufficiency Clinical Trial in Orlando, FL

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