NCT07766005 · Spyre Therapeutics, Inc.
A Study of SPY072 in Adults With Moderate to Severe Hidradenitis Suppurativa (The SKYLIGHT Trial)
What this study is about
This Phase 2 study will test whether the experimental medicine, SPY072, improves hidradenitis suppurativa (HS) in adults with moderate to severe disease receiving advanced the usual treatment treatment. About 150 participants will be assigned by chance to receive either SPY072 or placebo for 16 weeks.
View original scientific description
This Phase 2 study will test whether the investigational medicine, SPY072, improves hidradenitis suppurativa (HS) in adults with moderate to severe disease receiving advanced standard of care treatment. About 150 participants will be assigned by chance to receive either SPY072 or placebo for 16 weeks. Participants will be followed after the treatment period to evaluate safety and how long treatment effects may last.
Interventions
DRUG
SPY072
Solution for SC injection
DRUG
Placebo
Matching placebo for SC injection
DRUG
bimekizumab
Advanced standard of care
Primary outcome measures
Percentage of Participants Achieving Hidradenitis Suppurativa Clinical Response 75 (HiSCR75)
Time frame: Week 16
HiSCR75 is defined as at least a 75% reduction from baseline in total abscess and inflammatory nodule count, with no increase in abscess count and no increase in draining tunnel count
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Clinical diagnosis of Hidradenitis Suppurativa with symptoms for at least 6 months before screening.
- Hidradenitis suppurativa lesions in at least 2 distinct anatomical areas, with at least 1 area meeting Hurley Stage II or III criteria at screening and Day 1.
- Total abscess and/or inflammatory nodule count of at least 5 at screening and Day 1.
- Documented inadequate response, intolerance, or contraindication to at least 1 systemic therapy for hidradenitis suppurativa.
Exclusion criteria
- More than 20 draining tunnels at screening or Day 1.
- Hidradenitis suppurativa lesion expected to require incision and drainage within 4 weeks before Day 1, or major hidradenitis suppurativa surgery within 12 weeks before Day 1.
- Another inflammatory or skin condition that could interfere with assessment of hidradenitis suppurativa.
Where
- Birmingham, Alabama
- Rogers, Arkansas
- Irvine, California
- Coral Gables, Florida
- Atlanta, Georgia
- Indianapolis, Indiana
- Bowling Green, Kentucky
- Owensboro, Kentucky
- Baton Rouge, Louisiana
- Boston, Massachusetts
- Detroit, Michigan
- Las Vegas, Nevada
And 11 more locations — see the full list below.
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Oct 19, 2026 · Source of record for eligibility and locations