Is NCT05366270 recruiting in Boston, MA?

Yes, NCT05366270 is currently recruiting participants at its Boston, MA location. This hyperthermia clinical trial is actively enrolling qualified participants.

How do I join the hyperthermia clinical trial in Boston?

To join this clinical trial in Boston, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Boston clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Hyperthermia Clinical Trial in Boston, MA

About This Hyperthermia Study in Boston

The goal of this study is to examine how whole-body hyperthermia affects the thermoinflammatory profile, which includes the combined immune and heat shock response, in patients with depression and whether these changes correlate with decreased depression in individuals with Major Depressive Disorder.

Sponsor: Massachusetts General Hospital

Who Can Participate

Inclusion Criteria

Females and Males ages 18-65

English language proficiency

Ability to provide informed consent

Have a current primary psychiatric diagnosis of major depressive disorder (MDD) of at least 4 weeks duration, as defined by Diagnostic \& Statistical Manual, 5th Edition (DSM-5) criteria using the MINI.

Score of ≥ 24 on the Inventory of Depressive Symptomatology - Clinician Rated (IDS-CR)

Individuals of childbearing potential must use an acceptable form of birth control.

Exclusion Criteria

Pregnancy or planned pregnancy during study

Current breastfeeding

History of psychiatric hospitalization within the past year

Active suicidal intent ("yes" on item 4 or 5 on the Columbia-Suicide Severity Rating Scale)

History of bipolar disorder, psychotic disorders, eating disorders, and/or substance abuse or dependence (within the last year), as per the Mini-International Neuropsychiatric Interview (MINI)

Meeting DSM-5 criteria at screening for current obsessive compulsive disorder

A ≥25% drop in IDS-CR score from screen (V1) to baseline (V1b)

Positive urine toxicology screen due to illicit drug use or other exclusionary medications. (Potential false positives will be addressed on a case-by-case basis at the discretion of the investigator)

Serious unstable medical condition including cardiovascular, neurological, neoplastic, autoimmune, infectious or endocrine.

Morbid obesity (BMI \> 40) and/or body shape that might increase the risk of cutaneous burning from the Heckel hyperthermia device (because of truncal skin being too close to the infrared lights).

Any history of or current diagnosis of thrombosis or thrombophilia; if it is unclear whether a subject has received this diagnosis, a signed release will be obtained to contact the subject's treating physician and obtain accurate diagnostic information. Depending on the recommendation of the treating physician, the subject may undergo appropriate testing with the treating physician to verify the diagnosis, and if the tests produce negative findings, the subject may be allowed to enter the study

Has a history of or an increased risk for gastrointestinal perforation such as a history of diverticulitis, stomach or intestinal ulcers or abdominal pain that does not go away

Using medication that might impact thermoregulatory capacity within 3 days of receiving WBH treatment, including: diuretics, barbiturates, beta-blockers, antipsychotic agents, anti-cholinergic agents or chronic use of antihistamines, aspirin (other than low-dose for prophylactic purposes), non-steroidal anti-inflammatory drugs (NSAIDs), systemic corticosteroids, or cytokine antagonists.

Use of any medication that could interact in such a way as to potentiate the sedative effect of lorazepam or ondansetron, or otherwise deemed unsafe per physician judgment.

Fever (Temp \> 99) of unknown origin at the time of screen

Breast Implants

Unsafe cardiac status as defined by abnormal ECG reading at screening visit as determined by medical monitor, study doctor, or subject's primary care physician or cardiologist

Claustrophobia of sufficient severity to interfere with ability to enter/remain in Heckel device

A subject who in the opinion of the Principal Investigator would not be able to safely complete the study or would jeopardize study integrity

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT05366270) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Hyperthermia Treatment Options in Boston, MA

If you're searching for hyperthermia treatment options in Boston, MA, this clinical trial (NCT05366270) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced hyperthermia specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all hyperthermia clinical trials near you to find additional studies recruiting in your area.

Hyperthermia Clinical Trial in Boston, MA

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