Birmingham, ALNCT07818707Now EnrollingIRB Ready

Hypoglycemia Clinical Trial in Birmingham, AL

Access cutting-edge hypoglycemia treatment through this phase 4 clinical trial at a research site in Birmingham. Study-provided care at no cost to qualified participants.

Sponsored by Joslin Diabetes Center

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Expert Care in Birmingham

Access hypoglycemia specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related hypoglycemia treatment provided free

Apply for This Birmingham Location

Check if you qualify for this hypoglycemia clinical trial in Birmingham, AL

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Birmingham

    Convenient for AL residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Birmingham site if eligible
  4. 4Begin participation

About This Hypoglycemia Study in Birmingham

In this study, the investigators will determine (a) whether metabolism (secretion and turnover) of glucagon is altered in patients with PBH, (b) whether this is affected by a meal, (c) whether PBH affects the ability of the body to produce glucose (endogenous glucose production), and (d) whether PBH affects the amount of glycogen in the liver (storage form of glucose) when fasting and after a meal. The investigators will determine the effect of glucagon to raise glucose levels after a meal. To answer these questions, participants will receive an infusion of a stable (nonradioactive) isotope of glucose and glucagon, and a meal containing a stable isotope of glucose. Glycogen will be measured by magnetic resonance imaging (MRI) of the liver before and after the meal. This information will be used to develop computer models for the glucagon pump system.

Sponsor: Joslin Diabetes Center

Who Can Participate

Inclusion Criteria

Age 18-70 years of age, inclusive, at screening.
Willingness to provide informed consent and follow all study procedures, including attending all scheduled visits.
Males or females at least 2 years following Roux-en-Y gastric bypass (RYGB)
For patients recruited to PBH group: diagnosed with ongoing PBH, with documented episodes of hypoglycemia, and history of fulfillment of Whipple's triad.

Exclusion Criteria

Documented hypoglycemia occurring only in the fasting state (\>12 hours fast);
Current diabetes, defined as hemoglobin A1c \>6.5% or use of diabetes medications, except for acarbose or miglitol;
Chronic kidney disease stage 4 or 5 (including end-stage renal disease);
Hepatic disease, including serum ALT or AST greater than 2 times the upper limit of normal; hepatic synthetic insufficiency as defined as serum albumin \< 3.0 g/dL; or serum bilirubin \> 2.0;
Congestive heart failure, NYHA class II, III or IV;
History of myocardial infarction, unstable angina or revascularization within the past 6 months.
Two or more risk factors for coronary artery disease including diabetes, uncontrolled hypertension, uncontrolled hyperlipidemia, and active tobacco use.
History of recurrent syncope (unrelated to hypoglycemia) or active diagnosis of a cardiac arrhythmia;
Current administration of β-blocker therapy;
History of a cerebrovascular accident;
Seizure disorder (other than with suspect or documented hypoglycemia);
Active treatment with long-acting (LAR) octreotide or pasireotide;
Active malignancy, except basal cell or squamous cell skin cancers;
Personal or family history of pheochromocytoma or disorder with increased risk of pheochromocytoma (MEN 2, neurofibromatosis, or Von Hippel-Lindau disease);
Known insulinoma;
Major surgical operation within 30 days prior to screening;
Clinically significant anemia as defined as a hematocrit \< 33%;
Bleeding disorder, treatment with warfarin, or platelet count \<50,000;
Blood donation (1 pint of whole blood) within the past 2 months;
Active alcohol abuse or substance abuse;
Current administration of oral or parenteral corticosteroids;
Pregnancy and/ or lactation: For persons of childbearing potential: there is a requirement for a negative urine pregnancy test before any procedures.
Not enrolled in another study that uses an investigational drug for this condition.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Birmingham?

Yes, this clinical trial (NCT07818707) has an active research site in Birmingham, AL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Hypoglycemia Treatment Options in Birmingham, AL

If you're searching for hypoglycemia treatment options in Birmingham, AL, this clinical trial (NCT07818707) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Birmingham research site is actively enrolling participants for this phase 4 clinical trial. You'll receive care from experienced hypoglycemia specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all hypoglycemia clinical trials near you to find additional studies recruiting in your area.

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