NCT06470295 · University of Cincinnati
Effect of C-peptide on Hypoglycemic Counterregulation
What this study is about
Iatrogenic hypoglycemia is the most prominent barrier to the safe, effective management of blood sugar in people with type 1 diabetes due to periodic over-insulinization. During insulin-induced hypoglycemia, glucagon secretion is diminished in type 1 diabetes which, in turn, reduces hepatic glucose production and increases the depth and duration of hypoglycemic episodes.
View original scientific description
Iatrogenic hypoglycemia is the most prominent barrier to the safe, effective management of blood sugar in people with type 1 diabetes due to periodic over-insulinization. During insulin-induced hypoglycemia, glucagon secretion is diminished in type 1 diabetes which, in turn, reduces hepatic glucose production and increases the depth and duration of hypoglycemic episodes. We have observed that the naturally occurring protein C-peptide increases glucagon secretion in dogs during insulin-induced hypoglycemia, which increases hepatic glucose production; the experiments in this application will shed light on the translation of this finding to the human.
Interventions
OTHER
Saline
Normal saline will be infused during insulin-induced hypoglycemia
BIOLOGICAL
C-peptide
C-peptide will be infused during insulin-induced hypoglycemia
Primary outcome measures
Glucagon
Time frame: During procedure, up to 2.5 hours
from plasma
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- BMI less than 30 kg/m2
Exclusion criteria
- pregnant or lactating women cigarette smoking presence of HIV or hepatitis presence of cardiovascular disease presence of microvascular disease
Where
- Cincinnati, Ohio
Related conditions & keywords
Frequently asked questions
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Data: ClinicalTrials.gov · synced Feb 17, 2026 · Source of record for eligibility and locations